tert-butyl (2S)-2-(5-[7-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)isoquinolin-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Chemical Name:tert-butyl (2S)-2-(5-[7-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)isoquinolin-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate
CAS No.:1261072-11-0
Molecular Formula:C₄₅H₅₉N₇O₅Si
Molecular Weight:806.093
Hs Code.:

tert-butyl (2S)-2-(5-[7-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)isoquinolin-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Synonyms:tert-butyl (2S)-2-(5-[7-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)isoquinolin-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (2S)-2-(5-[7-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)isoquinolin-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (2S)-2-(5-[7-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)isoquinolin-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

There total 10 articles about tert-butyl (2S)-2-(5-[7-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)isoquinolin-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1261071-80-0
(2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1-{[2(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl)boronic acid

: 1261072-08-5
tert-butyl (2S)-2-{5-[4-(3-chloroisoquinolin-7-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

: 1261072-11-0
tert-butyl (2S)-2-(5-[7-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)isoquinolin-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: With potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; water; at 20 - 110 ℃; Inert atmosphere;

Reference yield:

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 1261072-11-0
tert-butyl (2S)-2-(5-[7-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)isoquinolin-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate; sodium hypochlorite; sodium bromide / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 1.5 h / 0 °C

1.2: 19 h / 20 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere

2.2: 1.5 h / 20 °C

3.1: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

4.1: TurboGrignard / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.2: 16 h / 20 °C

5.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 20 - 110 °C / Inert atmosphere

With sodium hypochlorite; potassium phosphate; N-Bromosuccinimide; TurboGrignard; sodium hydride; sodium hydrogencarbonate; sodium bromide; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1179149-96-2
tert-butyl (2S)-2-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1261072-11-0
tert-butyl (2S)-2-(5-[7-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)isoquinolin-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

2.1: TurboGrignard / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.2: 16 h / 20 °C

3.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 20 - 110 °C / Inert atmosphere

With potassium phosphate; N-Bromosuccinimide; TurboGrignard; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;