tert-butyl (2S)-2-{5-[4-(3-chloroisoquinolin-7-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (2S)-2-{5-[4-(3-chloroisoquinolin-7-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate
CAS No.:1261072-08-5
Molecular Formula:C₂₇H₂₇ClN₄O₂
Molecular Weight:474.99
Hs Code.:

Synonyms:tert-butyl (2S)-2-{5-[4-(3-chloroisoquinolin-7-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (2S)-2-{5-[4-(3-chloroisoquinolin-7-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (2S)-2-{5-[4-(3-chloroisoquinolin-7-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

There total 4 articles about tert-butyl (2S)-2-{5-[4-(3-chloroisoquinolin-7-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1007882-12-3
(S)-tert-butyl 2-(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1029720-65-7
7-bromo-3-chloroisoquinoline

: 1261072-08-5
tert-butyl (2S)-2-{5-[4-(3-chloroisoquinolin-7-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

Guidance literature:: With sodium carbonate; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); In 1,2-dimethoxyethane; water; at 120 ℃; for 0.333333h; sealed vial; Microwave irradiation;

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1261072-08-5
tert-butyl (2S)-2-{5-[4-(3-chloroisoquinolin-7-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.5 h / 0 - 20 °C

2.1: ammonium acetate / xylene / 5 h / 130 - 135 °C / Industry scale

3.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / Inert atmosphere; Reflux

3.2: pH ~ 8

4.1: sodium carbonate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / sealed vial; Microwave irradiation

With ammonium acetate; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; xylene;

Reference yield:

: 1007882-04-3
(S)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1261072-08-5
tert-butyl (2S)-2-{5-[4-(3-chloroisoquinolin-7-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / Inert atmosphere; Reflux

1.2: pH ~ 8

2.1: sodium carbonate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / sealed vial; Microwave irradiation

With potassium acetate; sodium carbonate; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; 1,2-dimethoxyethane; water;