di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-{4-[(tert-butoxycarbonyl)(2-hydroxy-ethyl)amino]benzyl}hexanedioate

Base Information

Chemical Name:di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-{4-[(tert-butoxycarbonyl)(2-hydroxy-ethyl)amino]benzyl}hexanedioate
CAS No.:1408449-65-9
Molecular Formula:C₃₃H₅₄N₂O₉
Molecular Weight:622.8
Hs Code.:

Synonyms:di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-{4-[(tert-butoxycarbonyl)(2-hydroxy-ethyl)amino]benzyl}hexanedioate

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Chemical Property of di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-{4-[(tert-butoxycarbonyl)(2-hydroxy-ethyl)amino]benzyl}hexanedioate

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Technology Process of di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-{4-[(tert-butoxycarbonyl)(2-hydroxy-ethyl)amino]benzyl}hexanedioate

There total 8 articles about di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-{4-[(tert-butoxycarbonyl)(2-hydroxy-ethyl)amino]benzyl}hexanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1408449-63-7
di-tert-butyl (5S)-2-(4-{[2-(benzyloxy)ethyl](tert-butoxycarbonyl)amino}benzyl)-5-[(tert-butoxycarbonyl)amino]hexanedioate

: 1408449-65-9
di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-{4-[(tert-butoxycarbonyl)(2-hydroxy-ethyl)amino]benzyl}hexanedioate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 27h;

Reference yield:

: 81323-58-2
N-(tert-butyloxycarbonyl)-(S)-homoserine tert-butyl ester

: 1408449-65-9
di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-{4-[(tert-butoxycarbonyl)(2-hydroxy-ethyl)amino]benzyl}hexanedioate

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-Bromosuccinimide / dichloromethane / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

2.2: 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h

3.2: 1.5 h / 60 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h

5.1: dmap / 1,4-dioxane / 6 h / Reflux

6.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 4 h / 20 °C

7.1: dichloromethane / 48 h / 20 °C

8.1: hydrogen / palladium 10% on activated carbon / methanol / 27 h

With dmap; N-Bromosuccinimide; hydrogen; sodium tris(acetoxy)borohydride; sodium hydride; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 163210-89-7
tert-butyl (S)-2-[(tert-butoxycarbonyl)amino]-4-bromobutanoate

: 1408449-65-9
di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-{4-[(tert-butoxycarbonyl)(2-hydroxy-ethyl)amino]benzyl}hexanedioate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

1.2: 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h

2.2: 1.5 h / 60 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h

4.1: dmap / 1,4-dioxane / 6 h / Reflux

5.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 4 h / 20 °C

6.1: dichloromethane / 48 h / 20 °C

7.1: hydrogen / palladium 10% on activated carbon / methanol / 27 h

With dmap; hydrogen; sodium tris(acetoxy)borohydride; sodium hydride; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;