Di-tert-butyl (5S)-2-(benzyloxycarbonyl)-5-[(tert-butoxycarbonyl)amino]hexane-dioate

Base Information

Chemical Name:Di-tert-butyl (5S)-2-(benzyloxycarbonyl)-5-[(tert-butoxycarbonyl)amino]hexane-dioate
CAS No.:1407507-30-5
Molecular Formula:C₂₇H₄₁NO₈
Molecular Weight:507.624
Hs Code.:

Synonyms:Di-tert-butyl (5S)-2-(benzyloxycarbonyl)-5-[(tert-butoxycarbonyl)amino]hexane-dioate

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Chemical Property of Di-tert-butyl (5S)-2-(benzyloxycarbonyl)-5-[(tert-butoxycarbonyl)amino]hexane-dioate

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Technology Process of Di-tert-butyl (5S)-2-(benzyloxycarbonyl)-5-[(tert-butoxycarbonyl)amino]hexane-dioate

There total 2 articles about Di-tert-butyl (5S)-2-(benzyloxycarbonyl)-5-[(tert-butoxycarbonyl)amino]hexane-dioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 72594-86-6
1-benzyl 3-(tert-butyl) malonate

: 163210-89-7
tert-butyl (S)-2-[(tert-butoxycarbonyl)amino]-4-bromobutanoate

: 1407507-30-5
Di-tert-butyl (5S)-2-(benzyloxycarbonyl)-5-[(tert-butoxycarbonyl)amino]hexane-dioate

Guidance literature:: 1-benzyl 3-(tert-butyl) malonate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h;

tert-butyl (S)-2-[(tert-butoxycarbonyl)amino]-4-bromobutanoate; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

Reference yield:

: 81323-58-2
N-(tert-butyloxycarbonyl)-(S)-homoserine tert-butyl ester

: 1407507-30-5
Di-tert-butyl (5S)-2-(benzyloxycarbonyl)-5-[(tert-butoxycarbonyl)amino]hexane-dioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / dichloromethane / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

2.2: 20 °C

With N-Bromosuccinimide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield: 88.0%

: 1407507-30-5
Di-tert-butyl (5S)-2-(benzyloxycarbonyl)-5-[(tert-butoxycarbonyl)amino]hexane-dioate

: 5544-60-5
4-(benzyloxy)benzyl bromide

: 1407507-31-6
di-tert-butyl (5S)-2-[4-(benzyloxy)benzyl]-2-(benzyloxycarbonyl)-5-[(tert-butoxy-carbonyl)amino]hexanedioate

Guidance literature:: Di-tert-butyl (5S)-2-(benzyloxycarbonyl)-5-[(tert-butoxycarbonyl)amino]hexane-dioate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h; Inert atmosphere;

4-(benzyloxy)benzyl bromide; In N,N-dimethyl-formamide; mineral oil; at 60 ℃; for 1h;