2-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-ylamino]-nicotinamide

Base Information

Chemical Name:2-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-ylamino]-nicotinamide
CAS No.:1207539-56-7
Molecular Formula:C₂₄H₂₂N₆O₂
Molecular Weight:426.478
Hs Code.:

Synonyms:2-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-ylamino]-nicotinamide

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Chemical Property of 2-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-ylamino]-nicotinamide

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Technology Process of 2-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-ylamino]-nicotinamide

There total 4 articles about 2-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-ylamino]-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 13438-65-8
2-aminopyridine-3-carboxamide

: 5-chloro-7-(4-morpholinophenyl)-[1,6]naphthyridine

: 1207539-56-7
2-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-ylamino]-nicotinamide

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; for 5h; Reflux;

Reference yield:

: 10282-31-2
4-morpholinobenzonitrile

: 1207539-56-7
2-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-ylamino]-nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 3 h / -65 - 0 °C / Inert atmosphere

1.2: -65 °C / Inert atmosphere

2.1: N,N-diethylaniline; trichlorophosphate / 120 °C

3.1: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 5 h / Reflux

With caesium carbonate; N,N-diethylaniline; lithium diisopropyl amide; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; toluene;

Reference yield:

: 7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-ol

: 1207539-56-7
2-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-ylamino]-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-diethylaniline; trichlorophosphate / 120 °C

2: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 5 h / Reflux

With caesium carbonate; N,N-diethylaniline; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene;