2-[2-(2-2-[4-(3-bromo-phenylamino)-6-nitro-quinazolin-7-yloxy]-ethoxyethoxy)-ethoxy]-ethanol

Base Information

• Chemical Name: 2-[2-(2-2-[4-(3-bromo-phenylamino)-6-nitro-quinazolin-7-yloxy]-ethoxyethoxy)-ethoxy]-ethanol
• CAS No.: 936942-17-5
• Molecular Formula: C₂₂H₂₅BrN₄O₇
• Molecular Weight: 537.367
• Mol file: 936942-17-5.mol

Synonyms:2-[2-(2-2-[4-(3-bromo-phenylamino)-6-nitro-quinazolin-7-yloxy]-ethoxyethoxy)-ethoxy]-ethanol

Chemical Property of 2-[2-(2-2-[4-(3-bromo-phenylamino)-6-nitro-quinazolin-7-yloxy]-ethoxyethoxy)-ethoxy]-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(2-2-[4-(3-bromo-phenylamino)-6-nitro-quinazolin-7-yloxy]-ethoxyethoxy)-ethoxy]-ethanol

There total 1 articles about 2-[2-(2-2-[4-(3-bromo-phenylamino)-6-nitro-quinazolin-7-yloxy]-ethoxyethoxy)-ethoxy]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

tetraethyleneglycol mono(tert-butyldimethylsilyl)ether (134179-40-1) + 4-[(3-bromophenyl)amino]-7-fluoro-6-nitro-quinazoline (174709-17-2) → 2-[2-(2-2-[4-(3-bromo-phenylamino)-6-nitro-quinazolin-7-yloxy]-ethoxyethoxy)-ethoxy]-ethanol (936942-17-5)

Guidance literature:

tetraethyleneglycol mono(tert-butyldimethylsilyl)ether; 4-[(3-bromophenyl)amino]-7-fluoro-6-nitro-quinazoline; With potassium trimethylsilonate; In dimethyl sulfoxide; at 20 ℃; for 2h;

With water; In ethyl acetate;

DOI:10.1002/jlcr.1569

Reference yield: 75.0%

2-[2-(2-2-[4-(3-bromo-phenylamino)-6-nitro-quinazolin-7-yloxy]-ethoxyethoxy)-ethoxy]-ethanol (936942-17-5) + p-toluenesulfonyl chloride (98-59-9) → C29H31BrN4O9S

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 2.5h; Inert atmosphere;

Reference yield:

2-[2-(2-2-[4-(3-bromo-phenylamino)-6-nitro-quinazolin-7-yloxy]-ethoxyethoxy)-ethoxy]-ethanol (936942-17-5) → C30H27BrF6N4O7

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 10 h / 40 °C / Inert atmosphere

With pyridine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

tetraethyleneglycol mono(tert-butyldimethylsilyl)ether

4-[(3-bromophenyl)amino]-7-fluoro-6-nitro-quinazoline