(E)-7-(4-Nitro-phenyl)-2-((E)-5-phenyl-pent-4-enyl)-hept-6-enoyl chloride

Base Information

Chemical Name:(E)-7-(4-Nitro-phenyl)-2-((E)-5-phenyl-pent-4-enyl)-hept-6-enoyl chloride
CAS No.:1026624-69-0
Molecular Formula:C₂₄H₂₆ClNO₃
Molecular Weight:411.928
Hs Code.:

Synonyms:(E)-7-(4-Nitro-phenyl)-2-((E)-5-phenyl-pent-4-enyl)-hept-6-enoyl chloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-7-(4-Nitro-phenyl)-2-((E)-5-phenyl-pent-4-enyl)-hept-6-enoyl chloride

Chemical Property:

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Technology Process of (E)-7-(4-Nitro-phenyl)-2-((E)-5-phenyl-pent-4-enyl)-hept-6-enoyl chloride

There total 12 articles about (E)-7-(4-Nitro-phenyl)-2-((E)-5-phenyl-pent-4-enyl)-hept-6-enoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 824431-63-2
(6E)-7-(p-nitrophenyl)-2-[(4E)-5-phenylpent-4-enyl]hept-6-enoic acid

: 1026624-69-0
(E)-7-(4-Nitro-phenyl)-2-((E)-5-phenyl-pent-4-enyl)-hept-6-enoyl chloride

Guidance literature:: With oxalyl dichloride; In toluene; at 120 ℃; for 2h;
DOI:10.1021/jo0483466

Reference yield:

: 636-98-6
p-nitrobenzene iodide

: 1026624-69-0
(E)-7-(4-Nitro-phenyl)-2-((E)-5-phenyl-pent-4-enyl)-hept-6-enoyl chloride

Guidance literature:: Multi-step reaction with 6 steps

1: PPh₃; NaOH / palladium(II) acetate / tetrahydrofuran / Heating

2: 3.09 g / hydrochloric acid / tetrahydrofuran / 4 h / 20 °C

3: 82 percent / I₂; PPh₃; imidazole / CH₂Cl₂ / 0 - 20 °C

4: 77 percent / cesium carbonate / acetonitrile / 72 h / 20 °C

5: 61 percent / H₂O / tetrahydrofuran / 4 h / 165 °C / microwave irradiation

6: oxalyl chloride / toluene / 2 h / 120 °C

With 1H-imidazole; hydrogenchloride; sodium hydroxide; oxalyl dichloride; water; iodine; caesium carbonate; triphenylphosphine; palladium diacetate; In tetrahydrofuran; dichloromethane; toluene; acetonitrile; 1: Suzuki coupling;
DOI:10.1021/jo0483466

Reference yield:

: 14371-10-9
(E)-3-phenylpropenal

: 1026624-69-0
(E)-7-(4-Nitro-phenyl)-2-((E)-5-phenyl-pent-4-enyl)-hept-6-enoyl chloride

Guidance literature:: Multi-step reaction with 8 steps

1: 71 percent / BH₃*HNMe₂ / methanol / 3 h / 20 °C

2: 90 percent / 1.5 h / 170 °C / microwave irradiation

3: 100 percent / DIBALH / tetrahydrofuran; CH₂Cl₂ / 4 h / -78 °C

4: 87 percent / DMSO; oxalyl chloride; triethylamine / CH₂Cl₂ / 5.25 h / -78 - 20 °C

5: 49 percent / BH₃*HNMe₂ / methanol / 3 h / 20 °C

6: 77 percent / cesium carbonate / acetonitrile / 72 h / 20 °C

7: 61 percent / H₂O / tetrahydrofuran / 4 h / 165 °C / microwave irradiation

8: oxalyl chloride / toluene / 2 h / 120 °C

With oxalyl dichloride; dimethylamine borane; water; diisobutylaluminium hydride; caesium carbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile; 1: Knoevenagel condensation / 4: Swern oxidation / 5: Knoevenagel condensation;
DOI:10.1021/jo0483466