(+/-)-methyl 2-hydroxy-2-(2-(methoxymethyl)phenyl)propionate

Base Information

• Chemical Name: (+/-)-methyl 2-hydroxy-2-(2-(methoxymethyl)phenyl)propionate
• CAS No.: 937255-88-4
• Molecular Formula: C₁₂H₁₆O₄
• Molecular Weight: 224.257
• Mol file: 937255-88-4.mol

Synonyms:(+/-)-methyl 2-hydroxy-2-(2-(methoxymethyl)phenyl)propionate

Chemical Property of (+/-)-methyl 2-hydroxy-2-(2-(methoxymethyl)phenyl)propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-methyl 2-hydroxy-2-(2-(methoxymethyl)phenyl)propionate

There total 1 articles about (+/-)-methyl 2-hydroxy-2-(2-(methoxymethyl)phenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

pyruvic acid methyl ester (600-22-6) + 1-bromo-2-(methoxymethyl)benzene (52711-30-5) → (+/-)-methyl 2-hydroxy-2-(2-(methoxymethyl)phenyl)propionate (937255-88-4)

Guidance literature:

1-bromo-2-(methoxymethyl)benzene; With iodine; magnesium; In tetrahydrofuran; at 20 ℃;

pyruvic acid methyl ester; In tetrahydrofuran; at 20 ℃; Further stages.;

DOI:10.1002/ejoc.200600856

Reference yield:

(+/-)-methyl 2-hydroxy-2-(2-(methoxymethyl)phenyl)propionate (937255-88-4) → (+/-)-2-methoxy-2-(2-(methoxymethyl)phenyl)propionic acid (937255-86-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / sodium hydride / tetrahydrofuran / 20 °C

2: 90 percent / aq. KOH / methanol / Heating

With potassium hydroxide; sodium hydride; In tetrahydrofuran; methanol;

DOI:10.1002/ejoc.200600856

Reference yield:

(+/-)-methyl 2-hydroxy-2-(2-(methoxymethyl)phenyl)propionate (937255-88-4) → (1R,3R,4S)-menthyl 2-methoxy-2-(2-(methoxymethyl)phenyl)propionate

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / sodium hydride / tetrahydrofuran / 20 °C

2: 90 percent / aq. KOH / methanol / Heating

3: DCC; DMAP; 10-camphorsulfonic acid / CH₂Cl₂ / 24 h / 20 °C

With dmap; potassium hydroxide; (1S)-10-camphorsulfonic acid; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1002/ejoc.200600856

upstream raw materials:

pyruvic acid methyl ester

1-bromo-2-(methoxymethyl)benzene

Downstream raw materials:

(+/-)-2-methoxy-2-(2-(methoxymethyl)phenyl)propionic acid