Synonyms:methyl pyruvate
98%, *data from raw suppliers
Methyl Pyruvate *data from reagent suppliers
There total 44 articles about Methyl pyruvate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 98.9%
Reference yield: 76.38%
Reference yield: 76.0%
The research investigates the reaction between dialkyl alkynylphosphonites and pyruvic acid methyl ester in boiling benzene, resulting in the formation of 1,1-dialkoxy-3,6-dimethyl-3,6-di(methoxycarbonyl)-4R-2,7-dioxa-1-phosphabicyclo[3.2.0]hept-4-enes. The study explores the reaction mechanism, which likely begins with a nucleophilic attack of a phosphorus atom on the carbon of a carbonyl group, followed by a series of transformations and additions leading to the formation of the final cyclic products. The compounds formed are a new type of unsaturated heterocycles containing phosphorus. The research also includes the analysis of the products using elemental analysis, 1H NMR, 31P NMR, and X-ray crystallography, confirming the structure and properties of the synthesized compounds.
The study reports the synthesis and crystal structure determination of 3-hydroxy-4-(4-methoxyphenyl)-5-(2-nitrophenyl)furan-2(5H)-one. The compound was synthesized using pyruvic acid (2-hydroxy-3-(4-methoxyphenyl)acrylic acid) as a starting material, which was converted to methyl pyruvate through a reaction with 1,5-diazabicyclo[5.4.0]undecene (DBU) and methyl iodide in dry DMF. The methyl pyruvate was then reacted with 2-nitrobenzaldehyde in the presence of DBU to form the title compound. The crystal structure was determined using single crystal X-ray diffraction. The compound crystallizes in the monoclinic space group C 2/c. The central furanone ring is nearly coplanar with the p-methoxybenzene ring and forms a dihedral angle of 87.2(1)° with the nitrobenzene ring. Intermolecular hydrogen bonds link pairs of molecules into centrosymmetric dimers, which are further assembled into chains along the [001] direction. The three-dimensional supramolecular architecture is stabilized by weak π–π interactions.
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