Benzeneacetamide, alpha-hydroxy-4-methyl-

Base Information

Chemical Name:Benzeneacetamide, alpha-hydroxy-4-methyl-
CAS No.:18584-26-4
Molecular Formula:C₉H₁₁NO₂
Molecular Weight:165.192
Hs Code.:
DSSTox Substance ID:DTXSID501297631

Synonyms:Benzeneacetamide, alpha-hydroxy-4-methyl-;18584-26-4;GIDDESIXRRHAJO-UHFFFAOYSA-N;DTXSID501297631;alpha-Hydroxy-4-methylbenzeneacetamide;AKOS011495154;2-hydroxy-2-(4-methylphenyl)acetamide

Suppliers and Price of Benzeneacetamide, alpha-hydroxy-4-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Benzeneacetamide, alpha-hydroxy-4-methyl-

Chemical Property:

XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:165.078978594
Heavy Atom Count:12
Complexity:162

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C(C(=O)N)O

Technology Process of Benzeneacetamide, alpha-hydroxy-4-methyl-

There total 5 articles about Benzeneacetamide, alpha-hydroxy-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 4815-10-5
2-hydroxy-2-(4-methylphenyl)acetonitrile

: 18584-26-4
2-hydroxy-2-p-tolylacetamide

Guidance literature:: With silver trifluoromethanesulfonate; C₃₃H₃₃ClO₇P₃Pt⁽¹⁺⁾*CF₃O₃S^(1-); In tetrahydrofuran; water; at 23 ℃; Catalytic behavior;
DOI:10.1021/acscatal.1c02254

Reference yield:

: 5524-56-1
ethyl 2-p-tolyl-2-oxoacetate

: 18584-26-4
2-hydroxy-2-p-tolylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide / tetrahydrofuran

2: acetyl chloride / methanol / 6 h / 0 °C / Inert atmosphere

3: ammonia / methanol / 2 h / 0 °C / Inert atmosphere

4: sodium tetrahydroborate / deuteromethanol

With sodium tetrahydroborate; ammonia; acetyl chloride; potassium hydroxide; In tetrahydrofuran; methanol; deuteromethanol;
DOI:10.1016/j.cattod.2012.03.081