2-(tert-butyl-dimethyl-silanyloxy)-3-(4-triisopropylsilanyloxy-phenyl)-propionaldehyde

Base Information

Chemical Name:2-(tert-butyl-dimethyl-silanyloxy)-3-(4-triisopropylsilanyloxy-phenyl)-propionaldehyde
CAS No.:320748-80-9
Molecular Formula:C₂₄H₄₄O₃Si₂
Molecular Weight:436.783
Hs Code.:

2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-(4-triisopropylsilanyloxy-phenyl)-propionaldehyde

Synonyms:2-(tert-butyl-dimethyl-silanyloxy)-3-(4-triisopropylsilanyloxy-phenyl)-propionaldehyde

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Chemical Property of 2-(tert-butyl-dimethyl-silanyloxy)-3-(4-triisopropylsilanyloxy-phenyl)-propionaldehyde

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Technology Process of 2-(tert-butyl-dimethyl-silanyloxy)-3-(4-triisopropylsilanyloxy-phenyl)-propionaldehyde

There total 6 articles about 2-(tert-butyl-dimethyl-silanyloxy)-3-(4-triisopropylsilanyloxy-phenyl)-propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 320748-79-6
2-(R)-(tert-butyldimethylsilanoxy)-3-(4-triisopropylsilanyloxyphenyl)-propan-1-ol

: 320748-80-9
2-(tert-butyl-dimethyl-silanyloxy)-3-(4-triisopropylsilanyloxy-phenyl)-propionaldehyde

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 ℃; for 0.75h;
DOI:10.1021/ol006759x

Reference yield:

: 106-41-2
4-bromo-phenol

: 320748-80-9
2-(tert-butyl-dimethyl-silanyloxy)-3-(4-triisopropylsilanyloxy-phenyl)-propionaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: 88 percent / imidazole / tetrahydrofuran / 36 h / 20 °C

2.1: t-BuLi / tetrahydrofuran; pentane / 0.17 h / -78 °C

2.2: 83 percent / CuBr*SMe₂; BF₃*OEt₂ / tetrahydrofuran; pentane / -45 - -20 °C

3.1: imidazole / CH₂Cl₂ / 11 h / 20 °C

4.1: 289 mg / H₂ / Pd/C / ethyl acetate / 50 h / 2280.15 Torr

5.1: 84 percent / Dess-Martin periodinone / CH₂Cl₂ / 0.75 h / 0 °C

With 1H-imidazole; hydrogen; tert.-butyl lithium; Dess-Martin periodane; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; pentane; 5.1: Dess-Martin oxidation;
DOI:10.1021/ol006759x

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 320748-80-9
2-(tert-butyl-dimethyl-silanyloxy)-3-(4-triisopropylsilanyloxy-phenyl)-propionaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: 88 percent / imidazole / tetrahydrofuran / 36 h / 20 °C

2.1: t-BuLi / tetrahydrofuran; pentane / 0.17 h / -78 °C

2.2: 83 percent / CuBr*SMe₂; BF₃*OEt₂ / tetrahydrofuran; pentane / -45 - -20 °C

3.1: imidazole / CH₂Cl₂ / 11 h / 20 °C

4.1: 289 mg / H₂ / Pd/C / ethyl acetate / 50 h / 2280.15 Torr

5.1: 84 percent / Dess-Martin periodinone / CH₂Cl₂ / 0.75 h / 0 °C

With 1H-imidazole; hydrogen; tert.-butyl lithium; Dess-Martin periodane; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; pentane; 5.1: Dess-Martin oxidation;
DOI:10.1021/ol006759x