Ethyl-carbamic acid (R)-2-(3,3-diethyl-1-methyl-ureido)-1-[3-(quinolin-2-ylmethoxy)-phenyl]-ethyl ester

Base Information

• Chemical Name: Ethyl-carbamic acid (R)-2-(3,3-diethyl-1-methyl-ureido)-1-[3-(quinolin-2-ylmethoxy)-phenyl]-ethyl ester
• CAS No.: 110193-21-0
• Molecular Formula: C₂₇H₃₄N₄O₄
• Molecular Weight: 478.591
• Mol file: 110193-21-0.mol

Synonyms:Ethyl-carbamic acid (R)-2-(3,3-diethyl-1-methyl-ureido)-1-[3-(quinolin-2-ylmethoxy)-phenyl]-ethyl ester

Chemical Property of Ethyl-carbamic acid (R)-2-(3,3-diethyl-1-methyl-ureido)-1-[3-(quinolin-2-ylmethoxy)-phenyl]-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl-carbamic acid (R)-2-(3,3-diethyl-1-methyl-ureido)-1-[3-(quinolin-2-ylmethoxy)-phenyl]-ethyl ester

There total 2 articles about Ethyl-carbamic acid (R)-2-(3,3-diethyl-1-methyl-ureido)-1-[3-(quinolin-2-ylmethoxy)-phenyl]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

2-Chloromethylquinoline (4377-41-7) + ethylcarbamic acid (1R)-2<<(ethylamino)carbonyl>methylamino>ethyl ester (110193-53-8) → Ethyl-carbamic acid (R)-2-(3,3-diethyl-1-methyl-ureido)-1-[3-(quinolin-2-ylmethoxy)-phenyl]-ethyl ester (110193-21-0)

Guidance literature:

With caesium carbonate; In acetone; for 48h; Heating;

DOI:10.1021/jm00394a026

Reference yield:

Phenylephrin (59-42-7) → Ethyl-carbamic acid (R)-2-(3,3-diethyl-1-methyl-ureido)-1-[3-(quinolin-2-ylmethoxy)-phenyl]-ethyl ester (110193-21-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / diethyl ether / Ambient temperature

2: 38 percent / cesium carbonate / acetone / 48 h / Heating

With caesium carbonate; triethylamine; In diethyl ether; acetone;

DOI:10.1021/jm00394a026

upstream raw materials:

2-Chloromethylquinoline

ethylcarbamic acid (1R)-2<<(ethylamino)carbonyl>methylamino>ethyl ester

Phenylephrin