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(R)-Phenylephrine (base and/or unspecified salts)
Cas No: 59-42-7
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
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Cas No: 59-42-7
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
Phenylephrine/ LIDE PHARMA- Factory supply / Best price
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Benzenemethanol,3-hydroxy-a-[(methylamino)methyl]-, (aR)- 59-42-7
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Phenylephrine 59-42-7
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Competitive Price phenylephrine CAS59-42-7
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High Purity Phenylephrine CAS 59-42-7
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USD $ 1.0-3.0 / Gram 10 Gram 1000 Kilogram/Month Wuhan Monad Medicine Tech Co.,LTD Contact Supplier
Phenylephrine CAS 59-42-7
Cas No: 59-42-7
USD $ 10.0-10.0 / Kilogram 1 Kilogram 200 Metric Ton/Month Hebei Guanlang Biotechnology Co., Ltd. Contact Supplier
Benzenemethanol,3-hydroxy-a-[(methylamino)methyl]-, (aR)-
Cas No: 59-42-7
No Data No Data No Data Shandong Hanjiang Chemical Co., Ltd. Contact Supplier

59-42-7 Usage

Brand name

Afrin 4 Hour Nasal Spray (Schering-Plough Health Care); Biomydrin (Parke-Davis); Mydfrin (Alcon); Neo-Synephrine (Sterling Health U.S.A.); Nostril (Boehringer Ingelheim).

Definition

ChEBI: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.

Uses

L-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 μM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 μM, respectively). By stimulating adrenergic α1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine. This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents. Because L-phenylephrine acts on adrenergic α1 receptors in the arterioles of the nasal mucosa to produce constriction, it has been examined clinically as an oral decongestant.
InChI:InChI=1/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1

59-42-7 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (P0395)  L-Phenylephrine  >98.0%(HPLC)(T) 59-42-7 25g 1,890.00CNY Detail
TCI America (P0395)  L-Phenylephrine  >98.0%(HPLC)(T) 59-42-7 5g 690.00CNY Detail

59-42-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name phenylephrine

1.2 Other means of identification

Product number -
Other names Mydfrin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:59-42-7 SDS

59-42-7Synthetic route

(S)-phenylephrine
614-03-9

(S)-phenylephrine

Phenylephrin
59-42-7

Phenylephrin

Conditions
ConditionsYield
Stage #1: (S)-phenylephrine With sulfuric acid; acetic anhydride at 105℃; for 12h; Walden inversion;
Stage #2: With water at 95℃; for 3h; Walden inversion; optical yield given as %ee; enantioselective reaction;
99%
With sulfuric acid; acetic anhydride und Erhitzen des Reaktionsprodukts mit wss.Salzsaeure und anschliessend mit wss.Ammoniak;
(R)-phenylephrine-(R)-naproxen
1280541-42-5

(R)-phenylephrine-(R)-naproxen

Phenylephrin
59-42-7

Phenylephrin

Conditions
ConditionsYield
Stage #1: (R)-phenylephrine-(R)-naproxen With hydrogenchloride In water; toluene at 75 - 80℃; for 0.5h; pH=< 2;
Stage #2: With ammonium hydroxide In water at 1 - 15℃; pH=~ 9; Product distribution / selectivity;
90%
α-methylamino-m-hydroxy-acetophenone sulfate

α-methylamino-m-hydroxy-acetophenone sulfate

Phenylephrin
59-42-7

Phenylephrin

Conditions
ConditionsYield
Stage #1: α-methylamino-m-hydroxy-acetophenone sulfate With hydrogen; (((R)-1-diphenylphosphino-2-[((S)-α-(N,N-dimethylamino)-o-diphenylphosphino-phenyl)methyl]ferrocene)-η5-2,4-dimethyl-pentadienyl)-ruthenium(II) iodide In methanol at 70℃; under 23272.3 Torr; for 48h;
Stage #2: With ammonium hydroxide In water at 65℃; for 0.0833333h; pH=~ 4.8 - 9;
88.7%
Phenylephrine
1477-63-0

Phenylephrine

Phenylephrin
59-42-7

Phenylephrin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Lg-tartaric acid
2: acetic acid anhydride; sulfuric acid / und Erhitzen des Reaktionsprodukts mit wss.Salzsaeure und anschliessend mit wss.Ammoniak
View Scheme
Multi-step reaction with 2 steps
1.1: methanol / 2 h / 20 - 65 °C / Resolution of racemate
2.1: hydrogenchloride / toluene; water / 0.5 h / 75 - 80 °C / pH < 2
2.2: 1 - 15 °C / pH ~ 9
View Scheme
3-Hydroxyphenyl-ω-methylaminoacetophenone hydrochloride
94240-17-2

3-Hydroxyphenyl-ω-methylaminoacetophenone hydrochloride

A

(S)-phenylephrine
614-03-9

(S)-phenylephrine

B

Phenylephrin
59-42-7

Phenylephrin

Conditions
ConditionsYield
With potassium hydroxide; hydrogen; [(R)-P-Phos RuCl2 (R)-DAIPEN] In water; isopropyl alcohol at 65℃; under 21002.1 Torr; for 1h; Product distribution / selectivity;A n/a
B n/a
With hydrogen; [(S)-Cl-MeO-Biphep RuCl2](dmf)n In methanol at 75℃; under 22502.3 Torr; for 18h; Product distribution / selectivity;A n/a
B n/a
With hydrogen; [RuCl-(S)-P-Phos(p-cymene)]Cl In methanol at 75℃; under 22502.3 Torr; for 18h; Product distribution / selectivity;A n/a
B n/a
3-Hydroxyphenyl-ω-methylaminoacetophenone hydrochloride
94240-17-2

3-Hydroxyphenyl-ω-methylaminoacetophenone hydrochloride

Phenylephrin
59-42-7

Phenylephrin

Conditions
ConditionsYield
With RuCl2[(S)-xylyl-2,2,6,6’-tetramethoxy-4,4’-bis(diphenylphosphino)-3,3-bipyridine][(R)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]; hydrogen; potassium hydroxide In water; isopropyl alcohol at 65℃; under 21752.2 - 24752.5 Torr; for 2.25h; Autoclave; optical yield given as %ee; enantioselective reaction;
(R)-1-(3-methoxyphenyl)-2-nitroethanol

(R)-1-(3-methoxyphenyl)-2-nitroethanol

Phenylephrin
59-42-7

Phenylephrin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 5%-palladium/activated carbon; hydrogen / methanol / 20 °C / 760.05 Torr
2: dichloromethane / 0 °C
3: boron tribromide / dichloromethane / 24 h / 0 °C
View Scheme
C10H15NO2
747358-03-8

C10H15NO2

Phenylephrin
59-42-7

Phenylephrin

Conditions
ConditionsYield
With boron tribromide In dichloromethane at 0℃; for 24h;
3-methoxy-benzaldehyde
591-31-1

3-methoxy-benzaldehyde

Phenylephrin
59-42-7

Phenylephrin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 2,6-dimethylpyridine; copper(II) choride dihydrate; C50H54N2O6 / ethanol; dichloromethane / 30 h / 20 °C
2: 5%-palladium/activated carbon; hydrogen / methanol / 20 °C / 760.05 Torr
3: dichloromethane / 0 °C
4: boron tribromide / dichloromethane / 24 h / 0 °C
View Scheme
(R)-2-N-tert-butoxycarbonyl-N-methylamino-1-(3-nitrophenyl)ethanol

(R)-2-N-tert-butoxycarbonyl-N-methylamino-1-(3-nitrophenyl)ethanol

Phenylephrin
59-42-7

Phenylephrin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper acetylacetonate; sodium tetrahydroborate / isopropyl alcohol; ethanol / 17 h / 30 °C / Inert atmosphere
2: hydrogenchloride; sodium nitrite / water / 0 - 120 °C
View Scheme
(R)-2-N-tert-butoxycarbonyl-N-methylamino-1-(3-aminophenyl)ethanol

(R)-2-N-tert-butoxycarbonyl-N-methylamino-1-(3-aminophenyl)ethanol

Phenylephrin
59-42-7

Phenylephrin

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite In water at 0 - 120℃;51.7 mg
Phenylephrin
59-42-7

Phenylephrin

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In isopropyl alcohol at 55 - 65℃; for 0.5h; Product distribution / selectivity;84.5%
With hydrogenchloride In water; isopropyl alcohol pH=7 - 8; enantioselective reaction;3.35 g
Phenylephrin
59-42-7

Phenylephrin

calcium carbide
75-20-7

calcium carbide

A

3-(2,2,3-trimethyl-oxazolidin-5-yl)-phenol
60052-56-4

3-(2,2,3-trimethyl-oxazolidin-5-yl)-phenol

B

m-(TRIMETHYLACETOXY)-α-[(METHYLAMINO)METHYL]BENZYL ALCOHOL HYDROCHLORIDE

m-(TRIMETHYLACETOXY)-α-[(METHYLAMINO)METHYL]BENZYL ALCOHOL HYDROCHLORIDE

Conditions
ConditionsYield
In acetoneA 70%
B n/a
3-naphthyl-1-phenyl-5-(5-fluoro-2-nitrophenyl)-2-pyrazoline

3-naphthyl-1-phenyl-5-(5-fluoro-2-nitrophenyl)-2-pyrazoline

Phenylephrin
59-42-7

Phenylephrin

C34H30N4O4

C34H30N4O4

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 4h; Reflux;63.2%
Phenylephrin
59-42-7

Phenylephrin

ethyl isocyanate
109-90-0

ethyl isocyanate

(1R)-1-(3-hydroxyphenyl)-2-<(ethylcarbamoyl)amino>ethanol
110193-48-1

(1R)-1-(3-hydroxyphenyl)-2-<(ethylcarbamoyl)amino>ethanol

Conditions
ConditionsYield
With triethylamine In diethyl ether Ambient temperature;21%
Phenylephrin
59-42-7

Phenylephrin

ethyl isocyanate
109-90-0

ethyl isocyanate

(1R)-1-(3-Hydroxyphenyl)-2-(N-ethylcarbamoyl)amino ethanol
126349-88-0

(1R)-1-(3-Hydroxyphenyl)-2-(N-ethylcarbamoyl)amino ethanol

Conditions
ConditionsYield
With triethylamine In diethyl ether21%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

Phenylephrin
59-42-7

Phenylephrin

(R)-5-(3-hydroxyphenyl)-3-methyl-2-oxazolidone
110193-49-2

(R)-5-(3-hydroxyphenyl)-3-methyl-2-oxazolidone

Conditions
ConditionsYield
With pyridine In dichloromethane at -78℃; for 0.5h;6%
Phenylephrin
59-42-7

Phenylephrin

(-)-1-acetoxy-1-(3-acetoxy-phenyl)-2-methylamino-ethane
63991-22-0

(-)-1-acetoxy-1-(3-acetoxy-phenyl)-2-methylamino-ethane

Phenylephrin
59-42-7

Phenylephrin

acetic anhydride
108-24-7

acetic anhydride

(R)-1-acetoxy-1-(3-acetoxy-phenyl)-2-(acetyl-methyl-amino)-ethane
94092-15-6

(R)-1-acetoxy-1-(3-acetoxy-phenyl)-2-(acetyl-methyl-amino)-ethane

bromocyane
506-68-3

bromocyane

Phenylephrin
59-42-7

Phenylephrin

3-(2-imino-3-methyl-oxazolidin-5-yl)-phenol

3-(2-imino-3-methyl-oxazolidin-5-yl)-phenol

Conditions
ConditionsYield
With sodium acetate In methanol
Phenylephrin
59-42-7

Phenylephrin

methyl isocyanate
624-83-9

methyl isocyanate

1-[(R)-2-Hydroxy-2-(3-hydroxy-phenyl)-ethyl]-1,3-dimethyl-urea

1-[(R)-2-Hydroxy-2-(3-hydroxy-phenyl)-ethyl]-1,3-dimethyl-urea

Conditions
ConditionsYield
With triethylamine In diethyl ether Ambient temperature;
Phenylephrin
59-42-7

Phenylephrin

ethyl isocyanate
109-90-0

ethyl isocyanate

ethylcarbamic acid (1R)-2<<(ethylamino)carbonyl>methylamino>ethyl ester
110193-53-8

ethylcarbamic acid (1R)-2<<(ethylamino)carbonyl>methylamino>ethyl ester

Conditions
ConditionsYield
With triethylamine In diethyl ether Ambient temperature;
Phenylephrin
59-42-7

Phenylephrin

1-{(R)-2-Hydroxy-2-[3-(quinolin-2-ylmethoxy)-phenyl]-ethyl}-1,3-dimethyl-urea
110193-26-5

1-{(R)-2-Hydroxy-2-[3-(quinolin-2-ylmethoxy)-phenyl]-ethyl}-1,3-dimethyl-urea

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / diethyl ether / Ambient temperature
2: 69 percent / cesium carbonate / acetone / 48 h / Heating
View Scheme
Phenylephrin
59-42-7

Phenylephrin

3-Ethyl-1-{(R)-2-hydroxy-2-[3-(quinolin-2-ylmethoxy)-phenyl]-ethyl}-1-methyl-urea
110193-25-4

3-Ethyl-1-{(R)-2-hydroxy-2-[3-(quinolin-2-ylmethoxy)-phenyl]-ethyl}-1-methyl-urea

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 21 percent / triethylamine / diethyl ether / Ambient temperature
2: 77 percent / cesium carbonate / acetone / 48 h / Heating
View Scheme
Phenylephrin
59-42-7

Phenylephrin

Ethyl-carbamic acid (R)-2-(3,3-diethyl-1-methyl-ureido)-1-[3-(quinolin-2-ylmethoxy)-phenyl]-ethyl ester; hydrochloride

Ethyl-carbamic acid (R)-2-(3,3-diethyl-1-methyl-ureido)-1-[3-(quinolin-2-ylmethoxy)-phenyl]-ethyl ester; hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / diethyl ether / Ambient temperature
2: 38 percent / cesium carbonate / acetone / 48 h / Heating
View Scheme
Phenylephrin
59-42-7

Phenylephrin

Ethyl-carbamic acid (R)-2-(3,3-diethyl-1-methyl-ureido)-1-[3-(quinolin-2-ylmethoxy)-phenyl]-ethyl ester
110193-21-0

Ethyl-carbamic acid (R)-2-(3,3-diethyl-1-methyl-ureido)-1-[3-(quinolin-2-ylmethoxy)-phenyl]-ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / diethyl ether / Ambient temperature
2: 38 percent / cesium carbonate / acetone / 48 h / Heating
View Scheme
Phenylephrin
59-42-7

Phenylephrin

2-dimethylamino-4-phenylpyrimidine-5-carboxylic acid
180283-80-1

2-dimethylamino-4-phenylpyrimidine-5-carboxylic acid

(L)-2-dimethylamino-4-phenylpyrimidine-5-carboxylic acid [2-hydroxy-2-(3-hydroxy-phenyl)ethyl]methyl amide

(L)-2-dimethylamino-4-phenylpyrimidine-5-carboxylic acid [2-hydroxy-2-(3-hydroxy-phenyl)ethyl]methyl amide

Conditions
ConditionsYield
Stage #1: Phenylephrin; 2-dimethylamino-4-phenylpyrimidine-5-carboxylic acid In tetrahydrofuran for 0.166667h;
Stage #2: With 4-methyl-morpholine In tetrahydrofuran for 0.0333333h;
Stage #3: With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In tetrahydrofuran at 20℃; for 4h; Heating / reflux;

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