(R)-phenylalanine N'-(benzyloxy)-N'-methylamide trifluoroacetate

Base Information

• Chemical Name: (R)-phenylalanine N'-(benzyloxy)-N'-methylamide trifluoroacetate
• CAS No.: 115364-62-0
• Molecular Formula: C₂HF₃O₂*C₁₇H₂₀N₂O₂
• Molecular Weight: 398.382
• Mol file: 115364-62-0.mol

Synonyms:(R)-phenylalanine N'-(benzyloxy)-N'-methylamide trifluoroacetate

Chemical Property of (R)-phenylalanine N'-(benzyloxy)-N'-methylamide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (R)-phenylalanine N'-(benzyloxy)-N'-methylamide trifluoroacetate

There total 3 articles about (R)-phenylalanine N'-(benzyloxy)-N'-methylamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(R)-N-tert-butyloxycarbonylphenylalanine N'-(benzyloxy)-N'-methylamide (115364-60-8) + trifluoroacetic acid (76-05-1) → (R)-phenylalanine N'-(benzyloxy)-N'-methylamide trifluoroacetate (115364-62-0)

Guidance literature:

In dichloromethane; at 0 ℃; for 1h;

DOI:10.1021/jm00117a025

Reference yield:

N-methyl-O-benzylhydroxylamine (22513-22-0) → (R)-phenylalanine N'-(benzyloxy)-N'-methylamide trifluoroacetate (115364-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 76.2 percent / triethylamine, 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / CHCl₃ / 1.) 0 deg C, 1 h, 2.) room temperature, overnight

2: 86 percent / CH₂Cl₂ / 1 h / 0 °C

With 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; chloroform;

DOI:10.1021/jm00117a025

Reference yield:

Boc-D-Phe-OH (18942-49-9) → (R)-phenylalanine N'-(benzyloxy)-N'-methylamide trifluoroacetate (115364-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 76.2 percent / triethylamine, 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / CHCl₃ / 1.) 0 deg C, 1 h, 2.) room temperature, overnight

2: 86 percent / CH₂Cl₂ / 1 h / 0 °C

With 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; chloroform;

DOI:10.1021/jm00117a025

upstream raw materials:

(R)-N-tert-butyloxycarbonylphenylalanine N'-(benzyloxy)-N'-methylamide

trifluoroacetic acid

N-methyl-O-benzylhydroxylamine

Boc-D-Phe-OH

Downstream raw materials:

(R)-N-(2-carboxy-1-oxoethyl)phenylalanine N'-(benzyloxy)-N'-methylamide

(R)-N-<2-(benzyloxycarbonyl)-1-oxoethyl>phenylalanine N'-(benzyloxy)-N'-methylamide