(S)-4-benzyl-3-((R)-3-cyclopentyl-3-hydroxy-4-pentynoyl)oxazolidin-2-one

Base Information

Chemical Name:(S)-4-benzyl-3-((R)-3-cyclopentyl-3-hydroxy-4-pentynoyl)oxazolidin-2-one
CAS No.:1508318-85-1
Molecular Formula:C₂₀H₂₃NO₄
Molecular Weight:341.407
Hs Code.:

Synonyms:(S)-4-benzyl-3-((R)-3-cyclopentyl-3-hydroxy-4-pentynoyl)oxazolidin-2-one

Suppliers and Price of (S)-4-benzyl-3-((R)-3-cyclopentyl-3-hydroxy-4-pentynoyl)oxazolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(S)-4-Benzyl-3-((R)-3-cyclopentyl-3-hydroxypent-4-ynoyl)oxazolidin-2-one 97%
1g
$ 1581.00

Total 2 raw suppliers

Chemical Property of (S)-4-benzyl-3-((R)-3-cyclopentyl-3-hydroxy-4-pentynoyl)oxazolidin-2-one

Chemical Property:

Boiling Point:542.3±40.0 °C(Predicted)
Density:1.273±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

(S)-4-Benzyl-3-((R)-3-cyclopentyl-3-hydroxypent-4-ynoyl)oxazolidin-2-one 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (S)-4-benzyl-3-((R)-3-cyclopentyl-3-hydroxy-4-pentynoyl)oxazolidin-2-one

There total 4 articles about (S)-4-benzyl-3-((R)-3-cyclopentyl-3-hydroxy-4-pentynoyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 70639-95-1
cyclopentyl ethynyl ketone

: 132836-66-9
(S)-3-acetyl-4-benzyloxazolidin-2-one

: 1508318-85-1
(S)-4-benzyl-3-((R)-3-cyclopentyl-3-hydroxy-4-pentynoyl)oxazolidin-2-one

: 1508318-97-5
C₁₉H₂₁NO₄

Guidance literature:: (S)-3-acetyl-4-benzyloxazolidin-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; toluene; at -85 - -70 ℃; for 2h; Large scale;

cyclopentyl ethynyl ketone; In tetrahydrofuran; toluene; for 4h; diastereoselective reaction; Large scale;
DOI:10.1021/op4002356

Reference yield:

: 70639-94-0
3-cyclopentyl-1-trimethylsilyl-1-propyn-3-one

: 1508318-85-1
(S)-4-benzyl-3-((R)-3-cyclopentyl-3-hydroxy-4-pentynoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / toluene; methanol / -5 - 0 °C / Large scale

2.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 2 h / -85 - -70 °C / Large scale

2.2: 4 h / Large scale

With N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; toluene; 2.1: |Evans Aldol Reaction;
DOI:10.1021/op4002356

Reference yield:

: 4524-93-0
Cyclopentanecarboxylic acid chloride

: 1508318-85-1
(S)-4-benzyl-3-((R)-3-cyclopentyl-3-hydroxy-4-pentynoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / toluene / 0.8 h / 15 - 35 °C / Inert atmosphere; Large scale

2.1: N-ethyl-N,N-diisopropylamine / toluene; methanol / -5 - 0 °C / Large scale

3.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 2 h / -85 - -70 °C / Large scale

3.2: 4 h / Large scale

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; toluene; 1.1: |Sonogashira Cross-Coupling / 3.1: |Evans Aldol Reaction;
DOI:10.1021/op4002356