N-Methoxy-N-methylcyclopentanecarboxamide

Base Information

• Chemical Name: N-Methoxy-N-methylcyclopentanecarboxamide
• CAS No.: 167303-65-3
• Molecular Formula: C8H15 N O2
• Molecular Weight: 157.213
• European Community (EC) Number: 857-156-5
• Nikkaji Number: J1.469.965A
• Mol file: 167303-65-3.mol

Synonyms:N-METHOXY-N-METHYLCYCLOPENTANECARBOXAMIDE;167303-65-3;N-methoxy-N-methyl-cyclopentanecarboxamide;Cyclopentanecarboxamide, N-methoxy-N-methyl- (9CI);N-Cyclopentanecarbonyl-N,O-dimethylhydroxylamine;SCHEMBL1341780;SHWIBMYQMRXLHI-UHFFFAOYSA-N;MFCD12546236;AKOS008953009;cyclopentyl-n-methoxy-n-methylcarboxamide;AM806352;AS-39660;N-methoxy-N-methyl-cyclopentane carboxamide;cyclopentanecarboxylic acid methoxy-methyl-amide;EN300-155608;Cyclopentanecarboxamide,N-methoxy-N-methyl-(9ci);F1903-0098

Chemical Property of N-Methoxy-N-methylcyclopentanecarboxamide

Chemical Property:

• Boiling Point: 200.5±23.0 °C(Predicted)
• PSA: 29.54000
• Density: 1.047±0.06 g/cm3(Predicted)
• LogP: 1.19640
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 157.110278721
• Heavy Atom Count: 11
• Complexity: 141

Purity/Quality:

97% ^*data from raw suppliers

N-methoxy-N-methylcyclopentanecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C(=O)C1CCCC1)OC

Technology Process of N-Methoxy-N-methylcyclopentanecarboxamide

There total 8 articles about N-Methoxy-N-methylcyclopentanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

cyclopentanecarboxylic acid (3400-45-1) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-Cyclopentanecarbonyl-N,O-dimethylhydroxylamine (167303-65-3)

Guidance literature:

cyclopentanecarboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 0.166667h;

N,O-dimethylhydroxylamine*hydrochloride; In acetonitrile; at 20 ℃; for 24h;

Reference yield: 97.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-Cyclopentanecarbonyl-N,O-dimethylhydroxylamine (167303-65-3)

Guidance literature:

cyclopentanecarboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 0.166667h;

N,O-dimethylhydroxylamine*hydrochloride; In acetonitrile; at 20 ℃; for 24h;

Reference yield: 85.0%

cyclopentanecarboxylic acid (3400-45-1) + N,0-dimethylhydroxylamine (1117-97-1) → N-Cyclopentanecarbonyl-N,O-dimethylhydroxylamine (167303-65-3)

Guidance literature:

cyclopentanecarboxylic acid; With N-ethyl-N,N-diisopropylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

N,0-dimethylhydroxylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h; Further stages.;

DOI:10.1021/ol000318w

upstream raw materials:

cyclopentanecarboxylic acid

N,0-dimethylhydroxylamine

cyclopentanecarbonyl fluoride

Cyclopentanecarboxylic acid chloride

Downstream raw materials:

cyclopentyl(2-methoxyphenyl)methanone

cyclopentyl-(2-hydroxy-phenyl)-methanone

2,2-spiropentanylbenzofuran-3-one

trifluoromethanesulfonic acid 2-cyclopentanecarbonylphenyl ester