benzhydryl (1S,5R,6S)-1-(2-p-methoxybenzyloxyethyl)-2-hydroxymethyl-6-<(1R)-1-triethylsilyloxyethyl>carbapen-2-em-3-carboxylate

Base Information

• Chemical Name: benzhydryl (1S,5R,6S)-1-(2-p-methoxybenzyloxyethyl)-2-hydroxymethyl-6-<(1R)-1-triethylsilyloxyethyl>carbapen-2-em-3-carboxylate
• CAS No.: 220430-17-1
• Molecular Formula: C₃₉H₄₉NO₇Si
• Molecular Weight: 671.906

Synonyms:benzhydryl (1S,5R,6S)-1-(2-p-methoxybenzyloxyethyl)-2-hydroxymethyl-6-<(1R)-1-triethylsilyloxyethyl>carbapen-2-em-3-carboxylate

Chemical Property of benzhydryl (1S,5R,6S)-1-(2-p-methoxybenzyloxyethyl)-2-hydroxymethyl-6-<(1R)-1-triethylsilyloxyethyl>carbapen-2-em-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzhydryl (1S,5R,6S)-1-(2-p-methoxybenzyloxyethyl)-2-hydroxymethyl-6-<(1R)-1-triethylsilyloxyethyl>carbapen-2-em-3-carboxylate

There total 16 articles about benzhydryl (1S,5R,6S)-1-(2-p-methoxybenzyloxyethyl)-2-hydroxymethyl-6-<(1R)-1-triethylsilyloxyethyl>carbapen-2-em-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-Methoxybenzyl bromide (2746-25-0) → benzhydryl (1S,5R,6S)-1-(2-p-methoxybenzyloxyethyl)-2-hydroxymethyl-6-<(1R)-1-triethylsilyloxyethyl>carbapen-2-em-3-carboxylate (220430-17-1)

Guidance literature:

Multi-step reaction with 15 steps

1: NaH / dimethylformamide / 1 h / Ambient temperature

2: O₃; dimethyl sulfide / CH₂Cl₂; methanol / 1.5 h / -78 °C

3: 60 percent / 3-quinuclidinol / neat (no solvent) / 48 h / Ambient temperature

4: 76 percent / NBS, dimethylsulfide / CH₂Cl₂; toluene / 15 h / Ambient temperature

5: 92 percent / zinc dust / dimethylformamide / 2 h / Ambient temperature

6: DIBAL-H / toluene; methanol / -78 - 0 °C

7: triethylamine / CH₂Cl₂ / 0.25 h / 0 °C

8: conc. HCl, acetic acid / acetonitrile / 0.5 h / 0 °C

9: imidazole / dimethylformamide / 0.33 h / 0 °C

10: 1.) O₃; 2.) dimethylsulfide / 1.) CH₂Cl₂, CH₃OH, -78 deg C, 40 min

11: 87 percent / 4 Angstroem molecular sieves / toluene / 3 h / Heating

12: 2,6-lutidine, thionyl chloride / tetrahydrofuran / 0.5 h / -40 °C

13: 2,6-lutidine, NaBr / tetrahydrofuran / 1 h / Ambient temperature

14: 59 percent / NaOMe / methanol / 3 h / 0 °C

15: toluene / 3 h / Heating

With 1H-imidazole; 2,6-dimethylpyridine; hydrogenchloride; N-Bromosuccinimide; thionyl chloride; dimethylsulfide; 4 A molecular sieve; sodium methylate; sodium hydride; diisobutylaluminium hydride; ozone; acetic acid; triethylamine; 3-quinuclidinol; sodium bromide; zinc; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.3987/COM-98-8302

Reference yield:

3-(p-methoxybenzyloxy)propanal (128461-65-4) → benzhydryl (1S,5R,6S)-1-(2-p-methoxybenzyloxyethyl)-2-hydroxymethyl-6-<(1R)-1-triethylsilyloxyethyl>carbapen-2-em-3-carboxylate (220430-17-1)

Guidance literature:

Multi-step reaction with 13 steps

1: 60 percent / 3-quinuclidinol / neat (no solvent) / 48 h / Ambient temperature

2: 76 percent / NBS, dimethylsulfide / CH₂Cl₂; toluene / 15 h / Ambient temperature

3: 92 percent / zinc dust / dimethylformamide / 2 h / Ambient temperature

4: DIBAL-H / toluene; methanol / -78 - 0 °C

5: triethylamine / CH₂Cl₂ / 0.25 h / 0 °C

6: conc. HCl, acetic acid / acetonitrile / 0.5 h / 0 °C

7: imidazole / dimethylformamide / 0.33 h / 0 °C

8: 1.) O₃; 2.) dimethylsulfide / 1.) CH₂Cl₂, CH₃OH, -78 deg C, 40 min

9: 87 percent / 4 Angstroem molecular sieves / toluene / 3 h / Heating

10: 2,6-lutidine, thionyl chloride / tetrahydrofuran / 0.5 h / -40 °C

11: 2,6-lutidine, NaBr / tetrahydrofuran / 1 h / Ambient temperature

12: 59 percent / NaOMe / methanol / 3 h / 0 °C

13: toluene / 3 h / Heating

With 1H-imidazole; 2,6-dimethylpyridine; hydrogenchloride; N-Bromosuccinimide; thionyl chloride; dimethylsulfide; 4 A molecular sieve; sodium methylate; diisobutylaluminium hydride; ozone; acetic acid; triethylamine; 3-quinuclidinol; sodium bromide; zinc; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.3987/COM-98-8302

Reference yield:

4-Methoxybenzyl alcohol (105-13-5) → benzhydryl (1S,5R,6S)-1-(2-p-methoxybenzyloxyethyl)-2-hydroxymethyl-6-<(1R)-1-triethylsilyloxyethyl>carbapen-2-em-3-carboxylate (220430-17-1)

Guidance literature:

Multi-step reaction with 16 steps

1: aq. HBr / 0.5 h / Ambient temperature

2: NaH / dimethylformamide / 1 h / Ambient temperature

3: O₃; dimethyl sulfide / CH₂Cl₂; methanol / 1.5 h / -78 °C

4: 60 percent / 3-quinuclidinol / neat (no solvent) / 48 h / Ambient temperature

5: 76 percent / NBS, dimethylsulfide / CH₂Cl₂; toluene / 15 h / Ambient temperature

6: 92 percent / zinc dust / dimethylformamide / 2 h / Ambient temperature

7: DIBAL-H / toluene; methanol / -78 - 0 °C

8: triethylamine / CH₂Cl₂ / 0.25 h / 0 °C

9: conc. HCl, acetic acid / acetonitrile / 0.5 h / 0 °C

10: imidazole / dimethylformamide / 0.33 h / 0 °C

11: 1.) O₃; 2.) dimethylsulfide / 1.) CH₂Cl₂, CH₃OH, -78 deg C, 40 min

12: 87 percent / 4 Angstroem molecular sieves / toluene / 3 h / Heating

13: 2,6-lutidine, thionyl chloride / tetrahydrofuran / 0.5 h / -40 °C

14: 2,6-lutidine, NaBr / tetrahydrofuran / 1 h / Ambient temperature

15: 59 percent / NaOMe / methanol / 3 h / 0 °C

16: toluene / 3 h / Heating

With 1H-imidazole; 2,6-dimethylpyridine; hydrogenchloride; N-Bromosuccinimide; thionyl chloride; dimethylsulfide; 4 A molecular sieve; hydrogen bromide; sodium methylate; sodium hydride; diisobutylaluminium hydride; ozone; acetic acid; triethylamine; 3-quinuclidinol; sodium bromide; zinc; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.3987/COM-98-8302

upstream raw materials:

[(2R,3S)-2-{(R)-3-Hydroxy-1-[2-(4-methoxy-benzyloxy)-ethyl]-2-oxo-propyl}-4-oxo-3-((R)-1-triethylsilanyloxy-ethyl)-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid benzhydryl ester

p-Methoxybenzyl bromide

3-(p-methoxybenzyloxy)propanal

4-Methoxybenzyl alcohol

Downstream raw materials:

benzhydryl (1S,5R,6S)-1-(2-p-methoxybenzyloxyethyl)-2-(1,3,4-thiadiazol-2-yl)thiomethyl-6-<(1R)-1-triethylsilyloxyethyl>carbapen-2-em-3-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 220430-17-1 benzhydryl (1S,5R,6S)-1-(2-p-methoxybenzyloxyethyl)-2-hydroxymethyl-6-<(1R)-1-triethylsilyloxyethyl>carbapen-2-em-3-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send