2-benzyloxymethyl-2-methoxymethoxy-butyric acid methyl ester

Base Information

Chemical Name:2-benzyloxymethyl-2-methoxymethoxy-butyric acid methyl ester
CAS No.:326476-79-3
Molecular Formula:C₁₅H₂₂O₅
Molecular Weight:282.337
Hs Code.:

Synonyms:2-benzyloxymethyl-2-methoxymethoxy-butyric acid methyl ester

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Chemical Property of 2-benzyloxymethyl-2-methoxymethoxy-butyric acid methyl ester

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Technology Process of 2-benzyloxymethyl-2-methoxymethoxy-butyric acid methyl ester

There total 11 articles about 2-benzyloxymethyl-2-methoxymethoxy-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 107-30-2
chloromethyl methyl ether

: 326476-77-1
2-benzyloxymethyl-2-hydroxy-butyric acid methyl ester

: 326476-79-3
2-benzyloxymethyl-2-methoxymethoxy-butyric acid methyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 4h; Heating;
DOI:10.1016/S0957-4166(00)00376-1

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 326476-79-3
2-benzyloxymethyl-2-methoxymethoxy-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 98 percent / p-toluenesulfonic acid / CH₂Cl₂ / 3 h / Heating

2: 95 percent / DIBAL / CH₂Cl₂ / -78 - 0 °C

3: 80 percent / oxalyl chloride; Me₂SO; Et₃N / CH₂Cl₂ / -78 - 20 °C

4: 2-methyl-2-butene; aq. NaClO₂; Na₂HPO₄ / 2-methyl-propan-2-ol / 1 h / 20 °C

5: DEPC; TEA / dimethylformamide / 5 h / 20 °C

6: 100 percent / aq. KOH / methanol / 3 h / 20 °C

7: 51 percent / n-BuLi; NBS / dimethylformamide / 26 h / 0 - 20 °C

8: 95 percent / n-Bu₃SnH; AIBN / benzene / 3 h / Heating

9: aq. KOH / 24 h / Heating

10: diethyl ether / 0 °C

11: 96 percent / NaH / tetrahydrofuran / 4 h / Heating

With potassium hydroxide; sodium chlorite; disodium hydrogenphosphate; N-Bromosuccinimide; n-butyllithium; 2-methyl-but-2-ene; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); TEA; tri-n-butyl-tin hydride; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; diethyl dicarbonate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol; benzene; 1: cycloacetalization / 2: Reduction / 3: Oxidation / 4: Oxidation / 5: Acylation / 6: Hydrolysis / 7: bromolactonization / 8: debromination / 9: Hydrolysis / 10: Methylation / 11: Alkylation;
DOI:10.1016/S0957-4166(00)00376-1

Reference yield:

: 104306-94-7
2-benzyloxymethyl-but-2-en-1-ol

: 326476-79-3
2-benzyloxymethyl-2-methoxymethoxy-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 80 percent / oxalyl chloride; Me₂SO; Et₃N / CH₂Cl₂ / -78 - 20 °C

2: 2-methyl-2-butene; aq. NaClO₂; Na₂HPO₄ / 2-methyl-propan-2-ol / 1 h / 20 °C

3: DEPC; TEA / dimethylformamide / 5 h / 20 °C

4: 100 percent / aq. KOH / methanol / 3 h / 20 °C

5: 51 percent / n-BuLi; NBS / dimethylformamide / 26 h / 0 - 20 °C

6: 95 percent / n-Bu₃SnH; AIBN / benzene / 3 h / Heating

7: aq. KOH / 24 h / Heating

8: diethyl ether / 0 °C

9: 96 percent / NaH / tetrahydrofuran / 4 h / Heating

With potassium hydroxide; sodium chlorite; disodium hydrogenphosphate; N-Bromosuccinimide; n-butyllithium; 2-methyl-but-2-ene; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); TEA; tri-n-butyl-tin hydride; sodium hydride; dimethyl sulfoxide; triethylamine; diethyl dicarbonate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol; benzene; 1: Oxidation / 2: Oxidation / 3: Acylation / 4: Hydrolysis / 5: bromolactonization / 6: debromination / 7: Hydrolysis / 8: Methylation / 9: Alkylation;
DOI:10.1016/S0957-4166(00)00376-1