104306-94-7Relevant academic research and scientific papers
Allylic alcohol synthesis by Ni-catalyzed direct and selective coupling of alkynes and methanol
Chen, Herong,Kong, Wangqing,Zhou, Zhijun
, p. 9372 - 9378 (2021/07/25)
Methanol is an abundant and renewable chemical raw material, but its use as a C1 source in C-C bond coupling reactions still constitutes a big challenge, and the known methods are limited to the use of expensive and noble metal catalysts such as Ru, Rh and Ir. We herein report nickel-catalyzed direct coupling of alkynes and methanol, providing direct access to valuable allylic alcohols in good yields and excellent chemo- and regioselectivity. The approach features a broad substrate scope and high atom-, step- and redox-economy. Moreover, this method was successfully extended to the synthesis of [5,6]-bicyclic hemiacetals through a cascade cyclization reaction of alkynones and methanol.
Enantioselective synthesis of (S)-N,N-diethyl-2-formyl-2-(methoxymethoxy)butyramide, a key intermediate for 20(S)-camptothecin analogues, via asymmetric bromolactonization
Jew, Sang-Sup,Roh, Eun-Young,Kim, Hee-Jin,Goo Kim, Myoung,Park, Hyeung-Geun
, p. 3985 - 3994 (2007/10/03)
A new enantioselective synthetic method for enantiomerically pure (S)-N,N-diethyl-2-formyl-2-(methoxymethoxy)butyramide 5, a versatile key intermediate has been developed employing asymmetric bromolactonization using (S)-proline as the chiral auxiliary. C
SYNTHESIS OF SESBANIMIDE: AN APPROACH FOR THE SYNTHESIS OF RING C
Rao, A. V. Rama,Yadav, J. S.,Naik, A. M.,Chaudhary, A. G.
, p. 993 - 994 (2007/10/02)
A simple method for the construction of C-ring of sesbanimide utilizing the condensation of 2-benzyloxymethylcrotyl bromide with an aldehyde in the presence of zinc as the key step is described.
