N¹-(carbobenzyloxy)-N⁴-<3-<(carbobenzyloxy)amino>butyryl>-1,4-diaminobutane

Base Information

• Chemical Name: N¹-(carbobenzyloxy)-N⁴-<3-<(carbobenzyloxy)amino>butyryl>-1,4-diaminobutane
• CAS No.: 137945-95-0
• Molecular Formula: C₂₄H₃₁N₃O₅
• Molecular Weight: 441.527
• Mol file: 137945-95-0.mol

Synonyms:N¹-(carbobenzyloxy)-N⁴-<3-<(carbobenzyloxy)amino>butyryl>-1,4-diaminobutane

Chemical Property of N¹-(carbobenzyloxy)-N⁴-<3-<(carbobenzyloxy)amino>butyryl>-1,4-diaminobutane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-(carbobenzyloxy)-N⁴-<3-<(carbobenzyloxy)amino>butyryl>-1,4-diaminobutane

There total 1 articles about N¹-(carbobenzyloxy)-N⁴-<3-<(carbobenzyloxy)amino>butyryl>-1,4-diaminobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

3-benzyloxycarbonylaminobutyric acid (51440-81-4) + N-benzyloxycarbonyl-1,4-butanediamine hydrochloride (18807-73-3) → N1-(carbobenzyloxy)-N4-<3-<(carbobenzyloxy)amino>butyryl>-1,4-diaminobutane (137945-95-0)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 36h;

DOI:10.1021/jm00082a013

Reference yield:

N1-(carbobenzyloxy)-N4-<3-<(carbobenzyloxy)amino>butyryl>-1,4-diaminobutane (137945-95-0) → 1,8-diamino-5-azanonane (137946-02-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol / 24 h / 2068.6 Torr

2: BH₃*THF / tetrahydrofuran / 1.) reflux, 48 h, 2.) RT, 24 h

With borane-THF; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jm00082a013

upstream raw materials:

3-benzyloxycarbonylaminobutyric acid

N-benzyloxycarbonyl-1,4-butanediamine hydrochloride

Downstream raw materials:

1,8-diamino-5-azanonane