3-(3-chlorophenyl)-N-(2,4-dimethoxybenzyl)-2-oxo-N-(1,3,4-thiadiazol-2-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

Base Information

• Chemical Name: 3-(3-chlorophenyl)-N-(2,4-dimethoxybenzyl)-2-oxo-N-(1,3,4-thiadiazol-2-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide
• CAS No.: 1450923-56-4
• Molecular Formula: C₂₄H₁₉ClN₄O₆S₂
• Molecular Weight: 559.023
• Mol file: 1450923-56-4.mol

Synonyms:3-(3-chlorophenyl)-N-(2,4-dimethoxybenzyl)-2-oxo-N-(1,3,4-thiadiazol-2-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

Chemical Property of 3-(3-chlorophenyl)-N-(2,4-dimethoxybenzyl)-2-oxo-N-(1,3,4-thiadiazol-2-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-chlorophenyl)-N-(2,4-dimethoxybenzyl)-2-oxo-N-(1,3,4-thiadiazol-2-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

There total 2 articles about 3-(3-chlorophenyl)-N-(2,4-dimethoxybenzyl)-2-oxo-N-(1,3,4-thiadiazol-2-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2,4-dimethoxybenzyl)-2-oxo-N-(1,3,4-thiadiazol-2-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide (1450923-55-3) + 3-chlorophenylboronic acid (63503-60-6) → 3-(3-chlorophenyl)-N-(2,4-dimethoxybenzyl)-2-oxo-N-(1,3,4-thiadiazol-2-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide (1450923-56-4)

Guidance literature:

With copper diacetate; triethylamine; In dichloromethane; at 20 ℃; for 48h; Molecular sieve; Sealed tube;

Reference yield:

2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonyl chloride (27685-90-1) + N-[(2,4-dimethoxyphenyl)methyl]-1,3,4-thiadiazol-2-amine (1235406-58-2) → 3-(3-chlorophenyl)-N-(2,4-dimethoxybenzyl)-2-oxo-N-(1,3,4-thiadiazol-2-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide (1450923-56-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0.17 h / -78 °C

1.2: 18 h / -78 - 20 °C

2.1: triethylamine; copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve; Sealed tube

With copper diacetate; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

3-(3-chlorophenyl)-N-(2,4-dimethoxybenzyl)-2-oxo-N-(1,3,4-thiadiazol-2-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide (1450923-56-4) → C14H11ClN4O3S2 (1450923-57-5)

Guidance literature:

3-(3-chlorophenyl)-N-(2,4-dimethoxybenzyl)-2-oxo-N-(1,3,4-thiadiazol-2-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide; With sodium hydroxide; In water; at 80 ℃; for 1h; Sealed tube;

With methanol;

upstream raw materials:

2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonyl chloride

N-[(2,4-dimethoxyphenyl)methyl]-1,3,4-thiadiazol-2-amine

N-(2,4-dimethoxybenzyl)-2-oxo-N-(1,3,4-thiadiazol-2-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

3-chlorophenylboronic acid

Downstream raw materials:

C₁₄H₁₁ClN₄O₃S₂