3,5-dimethoxybenzoyl fluoride

Base Information

• Chemical Name: 3,5-dimethoxybenzoyl fluoride
• CAS No.: 1251445-50-7
• Molecular Formula: C₉H₉FO₃
• Molecular Weight: 184.167
• Mol file: 1251445-50-7.mol

Synonyms:3,5-dimethoxybenzoyl fluoride

Chemical Property of 3,5-dimethoxybenzoyl fluoride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-dimethoxybenzoyl fluoride

There total 10 articles about 3,5-dimethoxybenzoyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,3,4,5,6-pentafluorobenzophenone (1536-23-8) + 4-cyanophenyl 3,5-dimethoxybenzoate (849182-19-0) → 3,5-dimethoxybenzoyl fluoride (1251445-50-7) + 1-benzoyl-4-(4-cyanophenoxy)-2,3,5,6-tetrafluorobenzene (1336943-54-4)

Guidance literature:

With hydridotetakis(triphenylphosphine)rhodium(I); cis-1,2-bis-(diphenylphosphino)ethene; In chlorobenzene; for 3h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2011.07.031

Reference yield: 86.0%

S-(p-tolyl) 3,5-dimethoxybenzothioate (53271-46-8) + (perfluorophenyl)(p-tolyl)sulfane (16495-78-6) → 3,5-dimethoxybenzoyl fluoride (1251445-50-7) + 2,3,5,6-tetrafluoro-1,4-bis(p-tolylthio)benzene (55677-92-4)

Guidance literature:

With hydridotetakis(triphenylphosphine)rhodium(I); 1,2-bis-(diphenylphosphino)ethane; In chlorobenzene; for 2h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2011.07.031

Reference yield: 79.0%

Hexafluorobenzene (392-56-3) + S-(p-tolyl) 3,5-dimethoxybenzothioate (53271-46-8) → 3,5-dimethoxybenzoyl fluoride (1251445-50-7) + (perfluorophenyl)(p-tolyl)sulfane (16495-78-6)

Guidance literature:

With hydridotetakis(triphenylphosphine)rhodium(I); 1,2-bis-(diphenylphosphino)ethane; In chlorobenzene; for 2h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2011.07.031

upstream raw materials:

Hexafluorobenzene

C₁₆H₁₆O₄S

S-(p-tolyl) 3,5-dimethoxybenzothioate

p-methoxybenzoyl fluoride

Downstream raw materials:

S-(p-tolyl) 3,5-dimethoxybenzothioate

p-methoxybenzoyl fluoride

diethyl(3,5-dimethoxybenzoyl)phosphine sulfide

Refernces

• 1、 Arisawa, Mieko,Yamada, Toru,Yamaguchi, Masahiko. "Rhodium-catalyzed interconversion between acid fluorides and thioesters controlled using heteroatom acceptors". supporting information; experimental part. p. 6090 - 6092. Retrieved 2011/01/04.