cyclohexyl-(6-piperazin-1-yl-4-thiazol-2-yl-[2,4']bipyridinyl-2'-yl)-amine

Base Information

Chemical Name:cyclohexyl-(6-piperazin-1-yl-4-thiazol-2-yl-[2,4']bipyridinyl-2'-yl)-amine
CAS No.:1201674-48-7
Molecular Formula:C₂₃H₂₈N₆S
Molecular Weight:420.582
Hs Code.:

Synonyms:cyclohexyl-(6-piperazin-1-yl-4-thiazol-2-yl-[2,4']bipyridinyl-2'-yl)-amine

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Chemical Property of cyclohexyl-(6-piperazin-1-yl-4-thiazol-2-yl-[2,4']bipyridinyl-2'-yl)-amine

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Technology Process of cyclohexyl-(6-piperazin-1-yl-4-thiazol-2-yl-[2,4']bipyridinyl-2'-yl)-amine

There total 8 articles about cyclohexyl-(6-piperazin-1-yl-4-thiazol-2-yl-[2,4']bipyridinyl-2'-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 175422-04-5
2,6-dibromo-4-nitropyridine

: 1201674-48-7
cyclohexyl-(6-piperazin-1-yl-4-thiazol-2-yl-[2,4']bipyridinyl-2'-yl)-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / 1,4-dioxane / 4 h / 110 °C

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere

3.1: 62 h / 107 °C

4.1: dmap / dichloromethane; acetonitrile / 4.5 h / 85 °C

5.1: potassium hydroxide / dimethyl sulfoxide / 1 h / 20 °C

6.1: triethylamine / dichloromethane / 0 - 20 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 21 h / 80 °C / Inert atmosphere

7.2: 1 h / 20 °C

With sodium carbonate; triethylamine; potassium hydroxide; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1201675-82-2
tert-butyl 4-(2'-[(tert-butoxycarbonyl)(cyclohexyl)amino]-4-{[(trifluoromethyl)sulfonyl]oxy}-2,4'-bipyridin-6-yl)piperazine-1-carboxylate

: 173382-28-0
thiazol-2-ylzinc(II) bromide

: 1201674-48-7
cyclohexyl-(6-piperazin-1-yl-4-thiazol-2-yl-[2,4']bipyridinyl-2'-yl)-amine

Guidance literature:: tert-butyl 4-(2'-[(tert-butoxycarbonyl)(cyclohexyl)amino]-4-{[(trifluoromethyl)sulfonyl]oxy}-2,4'-bipyridin-6-yl)piperazine-1-carboxylate; thiazol-2-ylzinc(II) bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 80 ℃; for 21h; Inert atmosphere;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With ammonia; In methanol;

Reference yield:

: 1201675-68-4
4-(6-bromo-4-nitropyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester

: 1201674-48-7
cyclohexyl-(6-piperazin-1-yl-4-thiazol-2-yl-[2,4']bipyridinyl-2'-yl)-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere

2.1: 62 h / 107 °C

3.1: dmap / dichloromethane; acetonitrile / 4.5 h / 85 °C

4.1: potassium hydroxide / dimethyl sulfoxide / 1 h / 20 °C

5.1: triethylamine / dichloromethane / 0 - 20 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 21 h / 80 °C / Inert atmosphere

6.2: 1 h / 20 °C

With sodium carbonate; triethylamine; potassium hydroxide; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; acetonitrile;