2-(4-hydroxy-3-nitro-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester

Base Information

Chemical Name:2-(4-hydroxy-3-nitro-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester
CAS No.:1168133-80-9
Molecular Formula:C₁₅H₁₈F₃NO₅
Molecular Weight:349.307
Hs Code.:

Synonyms:2-(4-hydroxy-3-nitro-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester

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Chemical Property of 2-(4-hydroxy-3-nitro-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester

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Technology Process of 2-(4-hydroxy-3-nitro-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester

There total 6 articles about 2-(4-hydroxy-3-nitro-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1168133-79-6
2-(4-amino-3-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester

: 1168133-80-9
2-(4-hydroxy-3-nitro-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester

Guidance literature:: 2-(4-amino-3-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester; With sulfuric acid; sodium nitrite; In water; at 0 ℃;

With copper(I) oxide; cuprous nitrate; In water; for 0.0833333h;

Reference yield:

: 10203-58-4
(2-methylpropyl)-propanedioic acid, diethyl ester

: 1168133-80-9
2-(4-hydroxy-3-nitro-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 - 20 °C

1.2: 48 h / 20 °C

2.1: acetic acid; sulfuric acid / water / 72 h / Reflux

3.1: sulfuric acid / Reflux

4.1: water; tin(ll) chloride / ethanol / 4 h / Reflux

5.1: sodium nitrite; sulfuric acid / water / 0.33 h / 0 °C

5.2: 0.08 h

With sulfuric acid; water; sodium hydride; acetic acid; tin(ll) chloride; sodium nitrite; In ethanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 118-83-2
5-chloro-2-nitrotrifluoromethylbenzene

: 1168133-80-9
2-(4-hydroxy-3-nitro-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 - 20 °C

1.2: 48 h / 20 °C

2.1: acetic acid; sulfuric acid / water / 72 h / Reflux

3.1: sulfuric acid / Reflux

4.1: water; tin(ll) chloride / ethanol / 4 h / Reflux

5.1: sodium nitrite; sulfuric acid / water / 0.33 h / 0 °C

5.2: 0.08 h

With sulfuric acid; water; sodium hydride; acetic acid; tin(ll) chloride; sodium nitrite; In ethanol; water; N,N-dimethyl-formamide; mineral oil;