2-(p-MEMoxyphenylpropionoyloxy)(a)-4-(3'-MEMoxy-4'-methoxyphenyl)(e)-trans-quinolizidine

Base Information

• Chemical Name: 2-(p-MEMoxyphenylpropionoyloxy)(a)-4-(3'-MEMoxy-4'-methoxyphenyl)(e)-trans-quinolizidine
• CAS No.: 77092-58-1
• Molecular Formula: C₃₃H₄₇NO₉
• Molecular Weight: 601.737

Synonyms:2-(p-MEMoxyphenylpropionoyloxy)(a)-4-(3'-MEMoxy-4'-methoxyphenyl)(e)-trans-quinolizidine

Chemical Property of 2-(p-MEMoxyphenylpropionoyloxy)(a)-4-(3'-MEMoxy-4'-methoxyphenyl)(e)-trans-quinolizidine

Chemical Property:

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Technology Process of 2-(p-MEMoxyphenylpropionoyloxy)(a)-4-(3'-MEMoxy-4'-methoxyphenyl)(e)-trans-quinolizidine

There total 2 articles about 2-(p-MEMoxyphenylpropionoyloxy)(a)-4-(3'-MEMoxy-4'-methoxyphenyl)(e)-trans-quinolizidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(2S,9aS)-4-[4-Methoxy-3-(2-methoxy-ethoxymethoxy)-phenyl]-octahydro-quinolizin-2-ol (69730-94-5,69730-95-6,82929-78-0,82929-79-1) + methyl 3-(p-MEMoxyphenyl)propionate (77092-56-9) → 2-(p-MEMoxyphenylpropionoyloxy)(a)-4-(3'-MEMoxy-4'-methoxyphenyl)(e)-trans-quinolizidine (77092-58-1)

Guidance literature:

With sodium hydride; In xylene; for 6h; Heating;

DOI:10.1016/0040-4020(80)85040-X

Reference yield:

3-(4-hydroxyphenyl)propionic acid methyl ester (5597-50-2) → 2-(p-MEMoxyphenylpropionoyloxy)(a)-4-(3'-MEMoxy-4'-methoxyphenyl)(e)-trans-quinolizidine (77092-58-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium hydride / 1.) toluene, reflux, 30 min, 2.) room temperature, 4 h

2: 81 percent / sodium hydride / xylene / 6 h / Heating

With sodium hydride; In xylene;

DOI:10.1016/0040-4020(80)85040-X

Reference yield: 71.0%

2-(p-MEMoxyphenylpropionoyloxy)(a)-4-(3'-MEMoxy-4'-methoxyphenyl)(e)-trans-quinolizidine (77092-58-1) → 2-(p-hydroxyphenylpropionyloxy)(a)-4-(3'-hydroxy-4'-methoxyphenyl)(e)-trans-quinolizidine (24806-81-3,24806-82-4,77092-61-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1016/0040-4020(80)85040-X

upstream raw materials:

(2S,9aS)-4-[4-Methoxy-3-(2-methoxy-ethoxymethoxy)-phenyl]-octahydro-quinolizin-2-ol

methyl 3-(p-MEMoxyphenyl)propionate

3-(4-hydroxyphenyl)propionic acid methyl ester

Downstream raw materials:

2-(p-hydroxyphenylpropionyloxy)(a)-4-(3'-hydroxy-4'-methoxyphenyl)(e)-trans-quinolizidine

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