Methyl 3-(4-hydroxyphenyl)propionate

Base Information

• Chemical Name: Methyl 3-(4-hydroxyphenyl)propionate
• CAS No.: 5597-50-2
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Hs Code.: 29181990
• Mol file: 5597-50-2.mol

Synonyms:Hydrocinnamicacid, p-hydroxy-, methyl ester (7CI,8CI);3-(4-Hydroxyphenyl)propanoic acidmethyl ester;3-(4-Hydroxyphenyl)propionic acid methyl ester;4-Hydroxybenzenepropanoic acid methyl ester;4-[2-(Methoxycarbonyl)ethyl]phenol;Dihydro-p-coumaric acid methyl ester;Methyl 3-(4-hydroxyphenyl)propanoate;Methyl 3-(4-hydroxyphenyl)propionate;Methyl 3-(p-hydroxyphenyl)propionate;Methyl 4-hydroxybenzenepropanoate;Methyl4-hydroxydihydrocinnamate;Methyl 4-hydroxyhydrocinnamate;Methyl4-hydroxyphenylpropionate;Methyl p-hydroxyhydrocinnamate;Methyl phloretate;Phloretic acid methyl ester;

Chemical Property of Methyl 3-(4-hydroxyphenyl)propionate

Chemical Property:

• Appearance/Colour: white transparent low melting mass
• Vapor Pressure: 1.21E-14mmHg at 25°C
• Melting Point: 39-41 °C(lit.)
• Refractive Index: 1.635
• Boiling Point: 228.5 °C at 760 mmHg
• PKA: 9.89±0.15(Predicted)
• Flash Point: 124 °C
• PSA: 46.53000
• Density: 1.146 g/cm³
• LogP: 1.49780
• Storage Temp.: 2-8°C
• Solubility.: Soluble in chloroform and methanol.

Purity/Quality:

99%min ^*data from raw suppliers

3-(4-Hydroxyphenyl)propionicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 3-(4-hydroxyphenyl)propionate may be used in the enzymatic coupling of saccharides to protein.

Technology Process of Methyl 3-(4-hydroxyphenyl)propionate

There total 41 articles about Methyl 3-(4-hydroxyphenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 4-hydroxyphenylpropionic acid (501-97-3) → 3-(4-hydroxyphenyl)propionic acid methyl ester (5597-50-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

DOI:10.1021/jm0155502

Reference yield: 99.0%

4-hydroxyphenylpropionic acid (501-97-3) + dimethyl sulfate (77-78-1) → 3-(4-hydroxyphenyl)propionic acid methyl ester (5597-50-2)

Guidance literature:

With potassium carbonate; In acetone; Heating;

DOI:10.1021/jo0015974

Reference yield: 98.0%

methyl 3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propionate (475272-11-8) → 3-(4-hydroxyphenyl)propionic acid methyl ester (5597-50-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 72h;

DOI:10.1016/j.tetlet.2004.06.104

upstream raw materials:

methanol

4-hydroxyphenylpropionic acid

methyl 4-hydroxycinnamate

methyl 3-(p-MEMoxyphenyl)propionate

Downstream raw materials:

3-{4-[3-(4-Chloro-phenoxy)-2-oxo-propoxy]-phenyl}-propionic acid methyl ester

3-{4-[3-(4-Chloro-phenoxy)-2-hydroxy-propoxy]-phenyl}-propionic acid methyl ester

3-{4-[3-(4-Chloro-phenylsulfanyl)-2-hydroxy-propoxy]-phenyl}-propionic acid methyl ester

methyl 3-<4-(2,3-epoxypropoxy)phenyl>propionate

Refernces

• 1、 -. "Preparation method of iprolol hydrochloride". Paragraph 0053-0055; 0074. . Retrieved 2021/10/11.
• 2、 Aguiar, Sandra I.,André, Ana S.,António, Jo?o P. M.,Bernardes, Gon?alo J. L.,Carvalho, Joana Inês,Dias, Joana N. R.,Faustino, Hélio,Gois, Pedro M. P.,Lopes, Ricardo M. R. M.,Veiros, Luis F.,da Silva, Frederico A.. "Diazaborines Are a Versatile Platform to Develop ROS-Responsive Antibody Drug Conjugates**". supporting information. p. 25914 - 25921. Retrieved 2021/11/09.