2-(4-Chlor-2-nitro-benzyl)-2-acetamino-malonsaeure-diethylester

Base Information

• Chemical Name: 2-(4-Chlor-2-nitro-benzyl)-2-acetamino-malonsaeure-diethylester
• CAS No.: 56465-80-6
• Molecular Formula: C₁₆H₁₉ClN₂O₇
• Molecular Weight: 386.789
• Mol file: 56465-80-6.mol

Synonyms:2-(4-Chlor-2-nitro-benzyl)-2-acetamino-malonsaeure-diethylester

Chemical Property of 2-(4-Chlor-2-nitro-benzyl)-2-acetamino-malonsaeure-diethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-Chlor-2-nitro-benzyl)-2-acetamino-malonsaeure-diethylester

There total 2 articles about 2-(4-Chlor-2-nitro-benzyl)-2-acetamino-malonsaeure-diethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-2-nitrotoluene (89-59-8) → 2-(4-Chlor-2-nitro-benzyl)-2-acetamino-malonsaeure-diethylester (56465-80-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NBS, (PhCO)2O₂ / CCl₄

2: (i) Na, EtOH, (ii) /BRN= 744136/

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane;

DOI:10.1021/jm00241a022

Reference yield:

4-chloro-2-nitrobenzyl bromide (52311-59-8) + 2-acetylaminomalonic acid diethyl ester (1068-90-2) → 2-(4-Chlor-2-nitro-benzyl)-2-acetamino-malonsaeure-diethylester (56465-80-6)

Guidance literature:

Multistep reaction; (i) Na, EtOH, (ii) /BRN= 744136/;

DOI:10.1021/jm00241a022

Reference yield:

2-(4-Chlor-2-nitro-benzyl)-2-acetamino-malonsaeure-diethylester (56465-80-6) → 4-Chlor-2-amino-phenylalanin (56433-10-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl

2: H₂ / Pt-C / methanol; H₂O

With hydrogenchloride; hydrogen; platinum on activated charcoal; In methanol; water;

DOI:10.1021/jm00241a022

upstream raw materials:

4-chloro-2-nitrobenzyl bromide

2-acetylaminomalonic acid diethyl ester

4-chloro-2-nitrotoluene

Downstream raw materials:

4-Chlor-2-nitro-phenylalanin

4-Chlor-2-amino-phenylalanin