(3-{[(3,5-bistrifluoromethylbenzyl)-(2-methyl-2H-tetrazol-5-yl)amino]-methyl}-5-ethynyl-pyridin-2-yl)cyclopentylmethylethylamine

Base Information

Chemical Name:(3-{[(3,5-bistrifluoromethylbenzyl)-(2-methyl-2H-tetrazol-5-yl)amino]-methyl}-5-ethynyl-pyridin-2-yl)cyclopentylmethylethylamine
CAS No.:957216-25-0
Molecular Formula:C₂₇H₂₉F₆N₇
Molecular Weight:565.565
Hs Code.:

Synonyms:(3-{[(3,5-bistrifluoromethylbenzyl)-(2-methyl-2H-tetrazol-5-yl)amino]-methyl}-5-ethynyl-pyridin-2-yl)cyclopentylmethylethylamine

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Chemical Property of (3-{[(3,5-bistrifluoromethylbenzyl)-(2-methyl-2H-tetrazol-5-yl)amino]-methyl}-5-ethynyl-pyridin-2-yl)cyclopentylmethylethylamine

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Technology Process of (3-{[(3,5-bistrifluoromethylbenzyl)-(2-methyl-2H-tetrazol-5-yl)amino]-methyl}-5-ethynyl-pyridin-2-yl)cyclopentylmethylethylamine

There total 8 articles about (3-{[(3,5-bistrifluoromethylbenzyl)-(2-methyl-2H-tetrazol-5-yl)amino]-methyl}-5-ethynyl-pyridin-2-yl)cyclopentylmethylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 957216-24-9
(3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-5-trimethylsilanylethynylpyridin-2-yl)cyclopentylmethylethylamine

: 957216-25-0
(3-{[(3,5-bistrifluoromethylbenzyl)-(2-methyl-2H-tetrazol-5-yl)amino]-methyl}-5-ethynyl-pyridin-2-yl)cyclopentylmethylethylamine

Guidance literature:: (3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-5-trimethylsilanylethynylpyridin-2-yl)cyclopentylmethylethylamine; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

With water; In tetrahydrofuran;

Reference yield:

: 943551-71-1
[3-({[3,5-bis(trifluoromethyl)benzyl](2-methyl-2H-tetrazol-5-yl)amino}methyl)-5-bromopyridin-2-yl](cyclopentylmethyl)ethylamine

: 957216-25-0
(3-{[(3,5-bistrifluoromethylbenzyl)-(2-methyl-2H-tetrazol-5-yl)amino]-methyl}-5-ethynyl-pyridin-2-yl)cyclopentylmethylethylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 80 °C

1.2: 8 h / 80 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 20 °C

With tetrabutyl ammonium fluoride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran;

Reference yield:

: 957216-46-5
(3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}pyridin-2-yl)cyclopentylmethylethylamine

: 957216-25-0
(3-{[(3,5-bistrifluoromethylbenzyl)-(2-methyl-2H-tetrazol-5-yl)amino]-methyl}-5-ethynyl-pyridin-2-yl)cyclopentylmethylethylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 0 °C

2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 80 °C

2.2: 8 h / 80 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 20 °C

With N-Bromosuccinimide; tetrabutyl ammonium fluoride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; N,N-dimethyl-formamide;