(3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-5-trimethylsilanylethynylpyridin-2-yl)cyclopentylmethylethylamine

Base Information

Chemical Name:(3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-5-trimethylsilanylethynylpyridin-2-yl)cyclopentylmethylethylamine
CAS No.:957216-24-9
Molecular Formula:C₃₀H₃₇F₆N₇Si
Molecular Weight:637.747
Hs Code.:

(3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-5-trimethylsilanylethynylpyridin-2-yl)cyclopentylmethylethylamine

Synonyms:(3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-5-trimethylsilanylethynylpyridin-2-yl)cyclopentylmethylethylamine

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Chemical Property of (3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-5-trimethylsilanylethynylpyridin-2-yl)cyclopentylmethylethylamine

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Technology Process of (3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-5-trimethylsilanylethynylpyridin-2-yl)cyclopentylmethylethylamine

There total 7 articles about (3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-5-trimethylsilanylethynylpyridin-2-yl)cyclopentylmethylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 943551-71-1
[3-({[3,5-bis(trifluoromethyl)benzyl](2-methyl-2H-tetrazol-5-yl)amino}methyl)-5-bromopyridin-2-yl](cyclopentylmethyl)ethylamine

: 1066-54-2
trimethylsilylacetylene

: 957216-24-9
(3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-5-trimethylsilanylethynylpyridin-2-yl)cyclopentylmethylethylamine

Guidance literature:: [3-({[3,5-bis(trifluoromethyl)benzyl](2-methyl-2H-tetrazol-5-yl)amino}methyl)-5-bromopyridin-2-yl](cyclopentylmethyl)ethylamine; trimethylsilylacetylene; With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; at 80 ℃;

With diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 80 ℃; for 8h;

Reference yield:

: 957216-46-5
(3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}pyridin-2-yl)cyclopentylmethylethylamine

: 957216-24-9
(3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-5-trimethylsilanylethynylpyridin-2-yl)cyclopentylmethylethylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 0 °C

2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 80 °C

2.2: 8 h / 80 °C

With N-Bromosuccinimide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide;

Reference yield:

: C₁₅H₂₄N₂O₃S

: 957216-24-9
(3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-5-trimethylsilanylethynylpyridin-2-yl)cyclopentylmethylethylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 3 h / -5 °C

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 0 °C

3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 80 °C

3.2: 8 h / 80 °C

With N-Bromosuccinimide; potassium tert-butylate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide;