2-methoxy-5-[(2R)-2-(piperazin-1-yl)propyl]benzenesulfonamide

Base Information

• Chemical Name: 2-methoxy-5-[(2R)-2-(piperazin-1-yl)propyl]benzenesulfonamide
• CAS No.: 1391850-36-4
• Molecular Formula: C₁₄H₂₃N₃O₃S
• Molecular Weight: 313.421
• Mol file: 1391850-36-4.mol

Synonyms:2-methoxy-5-[(2R)-2-(piperazin-1-yl)propyl]benzenesulfonamide

Chemical Property of 2-methoxy-5-[(2R)-2-(piperazin-1-yl)propyl]benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-5-[(2R)-2-(piperazin-1-yl)propyl]benzenesulfonamide

There total 5 articles about 2-methoxy-5-[(2R)-2-(piperazin-1-yl)propyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.7%

2-methoxy-5-{(2R)-2-[4-(benzenelsulfonyl)piperazin-1-yl]propyl}benzenesulfonamide → 2-methoxy-5-[(2R)-2-(piperazin-1-yl)propyl]benzenesulfonamide (1391850-36-4)

Guidance literature:

2-methoxy-5-{(2R)-2-[4-(benzenelsulfonyl)piperazin-1-yl]propyl}benzenesulfonamide; With hydrogen bromide; In acetic acid; at 70 - 75 ℃; for 3h; Industry scale;

With sodium hydroxide; In water; at 0 - 35 ℃; pH=12 - 14;

Reference yield:

2-methoxy-5-(2-oxopropyl)benzenesulfonamide (116091-63-5) → 2-methoxy-5-[(2R)-2-(piperazin-1-yl)propyl]benzenesulfonamide (1391850-36-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride / methanol / 5 h / 20 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 8 h / 20 °C / 2206.72 Torr

3.1: N-ethyl-N,N-diisopropylamine / 10 h / 125 - 130 °C

4.1: hydrogen bromide / acetic acid / 3 h / 70 - 75 °C / Industry scale

4.2: 0 - 35 °C / pH 12 - 14

With hydroxylamine hydrochloride; hydrogen bromide; hydrogen; N-ethyl-N,N-diisopropylamine; 5%-palladium/activated carbon; In methanol; acetic acid;

Reference yield:

5-(2-hydroxyiminopropyl)-2-methoxybenzenesulfonamide (944395-49-7) → 2-methoxy-5-[(2R)-2-(piperazin-1-yl)propyl]benzenesulfonamide (1391850-36-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen / 5%-palladium/activated carbon / methanol / 8 h / 20 °C / 2206.72 Torr

2.1: N-ethyl-N,N-diisopropylamine / 10 h / 125 - 130 °C

3.1: hydrogen bromide / acetic acid / 3 h / 70 - 75 °C / Industry scale

3.2: 0 - 35 °C / pH 12 - 14

With hydrogen bromide; hydrogen; N-ethyl-N,N-diisopropylamine; 5%-palladium/activated carbon; In methanol; acetic acid;

upstream raw materials:

2-methoxy-5-(2-oxopropyl)benzenesulfonamide

5-((R)-2-amino-1-propyl)-2-methoxybenzenesulphonamide

5-(2-hydroxyiminopropyl)-2-methoxybenzenesulfonamide

5-[(2R)-2-aminopropyl]-2-methoxybenzenesulfonamide D-mandelate

Downstream raw materials:

2-methoxy-5-[(2R)-2-(4-methylpiperazin-1-yl)propyl]benzenesulfonamide

2-methoxy-5-[(2R)-2-(4-ethylpiperazin-1-yl)propyl]benzenesulfonamide