4-(6-bromo-7-iodo-3H-imidazo[4,5-b]pyridin-2-yl)benzoic acid

Base Information

Chemical Name:4-(6-bromo-7-iodo-3H-imidazo[4,5-b]pyridin-2-yl)benzoic acid
CAS No.:1069131-85-6
Molecular Formula:C₁₃H₇BrIN₃O₂
Molecular Weight:444.026
Hs Code.:

Synonyms:4-(6-bromo-7-iodo-3H-imidazo[4,5-b]pyridin-2-yl)benzoic acid

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Chemical Property of 4-(6-bromo-7-iodo-3H-imidazo[4,5-b]pyridin-2-yl)benzoic acid

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Technology Process of 4-(6-bromo-7-iodo-3H-imidazo[4,5-b]pyridin-2-yl)benzoic acid

There total 5 articles about 4-(6-bromo-7-iodo-3H-imidazo[4,5-b]pyridin-2-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1069131-83-4
methyl 4-(6-bromo-7-iodo-3H-imidazo[4,5-b]pyridin-2-yl)benzoate

: 1069131-85-6
4-(6-bromo-7-iodo-3H-imidazo[4,5-b]pyridin-2-yl)benzoic acid

Guidance literature:: methyl 4-(6-bromo-7-iodo-3H-imidazo[4,5-b]pyridin-2-yl)benzoate; With lithium hydroxide; water; In tetrahydrofuran; at 100 ℃; for 0.166667h; Microwave irradiation;

With hydrogenchloride; water; In tetrahydrofuran;

Reference yield:

: 1679-64-7
Monomethyl terephthalate

: 1069131-85-6
4-(6-bromo-7-iodo-3H-imidazo[4,5-b]pyridin-2-yl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 20 °C

1.2: 0.08 h / 200 °C / Microwave irradiation

2.1: acetic acid; 3-chloro-benzenecarboperoxoic acid / 24 h / 20 °C

2.2: 0.08 h / 120 °C / Microwave irradiation

3.1: hydrogenchloride / methanol; diethyl ether; dichloromethane

3.2: 0.33 h / 160 °C / Microwave irradiation

4.1: lithium hydroxide; water / tetrahydrofuran / 0.17 h / 100 °C / Microwave irradiation

With hydrogenchloride; lithium hydroxide; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile;

Reference yield:

: 1069131-80-1
methyl 4-(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)benzoate

: 1069131-85-6
4-(6-bromo-7-iodo-3H-imidazo[4,5-b]pyridin-2-yl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; 3-chloro-benzenecarboperoxoic acid / 24 h / 20 °C

1.2: 0.08 h / 120 °C / Microwave irradiation

2.1: hydrogenchloride / methanol; diethyl ether; dichloromethane

2.2: 0.33 h / 160 °C / Microwave irradiation

3.1: lithium hydroxide; water / tetrahydrofuran / 0.17 h / 100 °C / Microwave irradiation

With hydrogenchloride; lithium hydroxide; water; acetic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;