6-bromo-7-iodo-2-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3H-imidazo[4,5-b]pyridine

Base Information

Chemical Name:6-bromo-7-iodo-2-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3H-imidazo[4,5-b]pyridine
CAS No.:1069132-04-2
Molecular Formula:C₁₈H₁₇BrIN₅O
Molecular Weight:526.174
Hs Code.:

Synonyms:6-bromo-7-iodo-2-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3H-imidazo[4,5-b]pyridine

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Chemical Property of 6-bromo-7-iodo-2-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3H-imidazo[4,5-b]pyridine

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Technology Process of 6-bromo-7-iodo-2-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3H-imidazo[4,5-b]pyridine

There total 6 articles about 6-bromo-7-iodo-2-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 109-01-3
1-methyl-piperazine

: 1069131-85-6
4-(6-bromo-7-iodo-3H-imidazo[4,5-b]pyridin-2-yl)benzoic acid

: 1069132-04-2
6-bromo-7-iodo-2-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3H-imidazo[4,5-b]pyridine

Guidance literature:: 4-(6-bromo-7-iodo-3H-imidazo[4,5-b]pyridin-2-yl)benzoic acid; With O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

1-methyl-piperazine; In N,N-dimethyl-formamide; for 1h;

Reference yield:

: 1679-64-7
Monomethyl terephthalate

: 1069132-04-2
6-bromo-7-iodo-2-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 20 °C

1.2: 0.08 h / 200 °C / Microwave irradiation

2.1: acetic acid; 3-chloro-benzenecarboperoxoic acid / 24 h / 20 °C

2.2: 0.08 h / 120 °C / Microwave irradiation

3.1: hydrogenchloride / methanol; diethyl ether; dichloromethane

3.2: 0.33 h / 160 °C / Microwave irradiation

4.1: lithium hydroxide; water / tetrahydrofuran / 0.17 h / 100 °C / Microwave irradiation

5.1: O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 1 h

With hydrogenchloride; lithium hydroxide; water; O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1069131-81-2
methyl 4-(6-bromo-7-chloro-3H-imidazo[4,5-b]pyridin-2-yl)benzoate

: 1069132-04-2
6-bromo-7-iodo-2-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / methanol; diethyl ether; dichloromethane

1.2: 0.33 h / 160 °C / Microwave irradiation

2.1: lithium hydroxide; water / tetrahydrofuran / 0.17 h / 100 °C / Microwave irradiation

3.1: O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 1 h

With hydrogenchloride; lithium hydroxide; water; O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;