C₁₈H₂₀FN₃O₅

Base Information

• Chemical Name: C₁₈H₂₀FN₃O₅
• CAS No.: 1418141-13-5
• Molecular Formula: C₁₈H₂₀FN₃O₅
• Molecular Weight: 377.372
• Mol file: 1418141-13-5.mol

Synonyms:C₁₈H₂₀FN₃O₅

Chemical Property of C₁₈H₂₀FN₃O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₀FN₃O₅

There total 6 articles about C₁₈H₂₀FN₃O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C24H34FN3O5Si (1418141-29-3) → C18H20FN3O5 (1418141-13-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 5 ℃; for 16h;

Reference yield:

C29H46FN3O5Si2 (1418141-26-0) → C18H20FN3O5 (1418141-13-5)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid; water / tetrahydrofuran / 5 h / 0 - 20 °C

2: Dess-Martin periodane / dichloromethane / 2 h / Inert atmosphere

3: tetrahydrofuran; diethyl ether / 5 h / -78 - 0.1 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 5 °C

With tetrabutyl ammonium fluoride; water; Dess-Martin periodane; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane;

Reference yield:

C23H32FN3O5Si (1418141-27-1) → C18H20FN3O5 (1418141-13-5)

Guidance literature:

Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 2 h / Inert atmosphere

2: tetrahydrofuran; diethyl ether / 5 h / -78 - 0.1 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 5 °C

With tetrabutyl ammonium fluoride; Dess-Martin periodane; In tetrahydrofuran; diethyl ether; dichloromethane;

upstream raw materials:

(2'R)-2'-deoxy-2'-fluoro-2'-methylcytidine

3′,5′-bis-O-tert-butyldimethylsilyl-2′-deoxy-2′-α-fluoro-2′-β-C-methylcytidine

C₂₉H₄₆FN₃O₅Si₂

C₂₃H₃₂FN₃O₅Si