3(S)-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide

Base Information

Chemical Name:3(S)-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide
CAS No.:888073-37-8
Molecular Formula:C₁₄H₁₀F₆N₄S
Molecular Weight:380.317
Hs Code.:

Synonyms:3(S)-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide

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Chemical Property of 3(S)-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide

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Technology Process of 3(S)-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide

There total 5 articles about 3(S)-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90357-53-2
N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide

: 888073-37-8
3(S)-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / 0 - 70 °C

2: Lawesson's reagent / toluene / 6 h / Heating

3: enantioselective separation on Chiral Pak column

With Lawessons reagent; sodium hydride; In toluene;
DOI:10.1016/j.bmcl.2006.10.035

Reference yield:

: 888071-58-7
3-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carboxylic acid (4-cyano-3-trifluoromethyl-phenyl)-amide

: 888073-37-8
3(S)-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: Lawesson's reagent / toluene / 6 h / Heating

2: enantioselective separation on Chiral Pak column

With Lawessons reagent; In toluene;
DOI:10.1016/j.bmcl.2006.10.035

Reference yield:

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 888073-37-8
3(S)-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 0 - 20 °C

2: NaH / 0 - 70 °C

3: Lawesson's reagent / toluene / 6 h / Heating

4: enantioselective separation on Chiral Pak column

With Lawessons reagent; thionyl chloride; sodium hydride; In toluene;
DOI:10.1016/j.bmcl.2006.10.035