4-(6-amino-3aS-methyl-2-trifluoromethyl-3,3a-dihydro-imidazo[1,5-b]pyrazol-4-ylideneamino)-2-trifluoromethyl-benzonitrile

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Chemical Name:4-(6-amino-3aS-methyl-2-trifluoromethyl-3,3a-dihydro-imidazo[1,5-b]pyrazol-4-ylideneamino)-2-trifluoromethyl-benzonitrile
CAS No.:924290-05-1
Molecular Formula:C₁₅H₁₀F₆N₆
Molecular Weight:388.275
Hs Code.:

Synonyms:4-(6-amino-3aS-methyl-2-trifluoromethyl-3,3a-dihydro-imidazo[1,5-b]pyrazol-4-ylideneamino)-2-trifluoromethyl-benzonitrile

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Chemical Property of 4-(6-amino-3aS-methyl-2-trifluoromethyl-3,3a-dihydro-imidazo[1,5-b]pyrazol-4-ylideneamino)-2-trifluoromethyl-benzonitrile

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Technology Process of 4-(6-amino-3aS-methyl-2-trifluoromethyl-3,3a-dihydro-imidazo[1,5-b]pyrazol-4-ylideneamino)-2-trifluoromethyl-benzonitrile

There total 7 articles about 4-(6-amino-3aS-methyl-2-trifluoromethyl-3,3a-dihydro-imidazo[1,5-b]pyrazol-4-ylideneamino)-2-trifluoromethyl-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90357-53-2
N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide

: 924290-05-1
4-(6-amino-3aS-methyl-2-trifluoromethyl-3,3a-dihydro-imidazo[1,5-b]pyrazol-4-ylideneamino)-2-trifluoromethyl-benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: NaH / 0 - 70 °C

2: Lawesson's reagent / toluene / 6 h / Heating

3: enantioselective separation on Chiral Pak column

4: acetone / 50 - 70 °C

5: K₂CO₃ / dioxane / 100 °C

With Lawessons reagent; sodium hydride; potassium carbonate; In 1,4-dioxane; acetone; toluene;
DOI:10.1016/j.bmcl.2006.10.035

Reference yield:

: N-(4-cyano-3-trifluoromethyl-phenyl)-3(S)-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carboximidothioic acid ethyl ester

: 420-04-2
CYANAMID

: 924290-05-1
4-(6-amino-3aS-methyl-2-trifluoromethyl-3,3a-dihydro-imidazo[1,5-b]pyrazol-4-ylideneamino)-2-trifluoromethyl-benzonitrile

Guidance literature:: With potassium carbonate; In 1,4-dioxane; at 100 ℃;
DOI:10.1016/j.bmcl.2006.10.035

Reference yield:

: 888073-20-9
3-methyl-5-fluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide

: 924290-05-1
4-(6-amino-3aS-methyl-2-trifluoromethyl-3,3a-dihydro-imidazo[1,5-b]pyrazol-4-ylideneamino)-2-trifluoromethyl-benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: enantioselective separation on Chiral Pak column

2: acetone / 50 - 70 °C

3: K₂CO₃ / dioxane / 100 °C

With potassium carbonate; In 1,4-dioxane; acetone;
DOI:10.1016/j.bmcl.2006.10.035