(2S,3S)-2-Benzyl-5-oxo-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Name:(2S,3S)-2-Benzyl-5-oxo-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:210964-93-5
Molecular Formula:C₃₃H₄₇NO₄
Molecular Weight:521.74
Hs Code.:

Synonyms:(2S,3S)-2-Benzyl-5-oxo-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (2S,3S)-2-Benzyl-5-oxo-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (2S,3S)-2-Benzyl-5-oxo-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 1 articles about (2S,3S)-2-Benzyl-5-oxo-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 210964-89-9
(+)-(4S,5S)-5-benzyl-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone

: 210964-93-5
(2S,3S)-2-Benzyl-5-oxo-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jo9801162

Reference yield:

: 210964-93-5
(2S,3S)-2-Benzyl-5-oxo-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidine-1-carboxylic acid tert-butyl ester

: 125356-66-3,119463-16-0
(+)-preussin

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) triethylsilane, boron trifluoride etherate / 1) THF, -80 deg C, 30 min; 2) CH₂Cl₂, -90 to -40 deg C (slowly), -40 deg C, 1 h

2: 100 percent / CF₃COOH / 1 h / 20 °C

3: 78 percent / acetic acid, sodium cyanoborohydride / acetonitrile / 4 h / 20 °C

With triethylsilane; boron trifluoride diethyl etherate; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In acetonitrile;
DOI:10.1021/jo9801162

Reference yield:

: 210964-93-5
(2S,3S)-2-Benzyl-5-oxo-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidine-1-carboxylic acid tert-butyl ester

: 210964-94-6
(+)-(2S,3S,5R)-2-benzyl-3-hydroxy-5-nonylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) triethylsilane, boron trifluoride etherate / 1) THF, -80 deg C, 30 min; 2) CH₂Cl₂, -90 to -40 deg C (slowly), -40 deg C, 1 h

2: 100 percent / CF₃COOH / 1 h / 20 °C

With triethylsilane; boron trifluoride diethyl etherate; trifluoroacetic acid;
DOI:10.1021/jo9801162