[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ⁶-sulfanyl)phenyl]methanol

Base Information

• Chemical Name: [3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ⁶-sulfanyl)phenyl]methanol
• CAS No.: 1604819-37-5
• Molecular Formula: C₁₇H₁₁F₈N₃OS
• Molecular Weight: 457.347

Synonyms:[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ⁶-sulfanyl)phenyl]methanol

Chemical Property of [3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ⁶-sulfanyl)phenyl]methanol

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of [3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ⁶-sulfanyl)phenyl]methanol

There total 2 articles about [3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ⁶-sulfanyl)phenyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-4-(2,4-difluorophenyl)-5-fluoropyrimidine (1402545-53-2) + [3-amino-5-(pentafluoro-λ6-sulfanyl)phenyl]methanol (1427316-37-7) → [3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ6-sulfanyl)phenyl]methanol (1604819-37-5)

Guidance literature:

With trifluoroacetic acid; In butan-1-ol; at 140 ℃; for 17h; Sealed tube;

Reference yield:

2,4-difluorophenylboronic acid (144025-03-6) → [3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ6-sulfanyl)phenyl]methanol (1604819-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,2-dimethoxyethane / 1.5 h / 90 °C / Inert atmosphere

2: trifluoroacetic acid / butan-1-ol / 17 h / 140 °C / Sealed tube

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; trifluoroacetic acid; In 1,2-dimethoxyethane; butan-1-ol;

Reference yield:

[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ6-sulfanyl)phenyl]methanol (1604819-37-5) → N-[3-(chloromethyl)-5-(pentafluoro-λ6-sulfanyl)phenyl]-4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-amine (1604819-38-6)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 25 ℃; for 3h;

upstream raw materials:

2-chloro-4-(2,4-difluorophenyl)-5-fluoropyrimidine

[3-amino-5-(pentafluoro-λ⁶-sulfanyl)phenyl]methanol

2,4-difluorophenylboronic acid

Downstream raw materials:

N-[3-(chloromethyl)-5-(pentafluoro-λ⁶-sulfanyl)phenyl]-4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-amine

(rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ⁶-sulfanyl)benzyl](methyl)-λ⁴-sulfanylidene}cyanamide

(rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ⁶-sulfanyl)benzyl](methyl)oxido-λ⁶-sulfanylidene}cyanamide

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