5-chloro-2-phenylindoline

Base Information

• Chemical Name: 5-chloro-2-phenylindoline
• CAS No.: 593234-34-5
• Molecular Formula: C₁₄H₁₂ClN
• Molecular Weight: 229.709
• Mol file: 593234-34-5.mol

Synonyms:5-chloro-2-phenylindoline

Chemical Property of 5-chloro-2-phenylindoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 5-chloro-2-phenylindoline

There total 1 articles about 5-chloro-2-phenylindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

5-chloro-2-phenylindole (23746-76-1) → 5-chloro-2-phenylindoline (593234-34-5)

Guidance literature:

With hydrogenchloride; tin; In ethanol; water; at 20 - 90 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ja406004q

Reference yield: 66.0%

di-tert-butyl dicarbonate (24424-99-5) + 5-chloro-2-phenylindoline (593234-34-5) → tert-butyl 5-chloro-2-phenyl-2,3-dihydroindole-1-carboxylate

Guidance literature:

5-chloro-2-phenyl-2,3-dihydro-1H-indole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

di-tert-butyl dicarbonate; In tetrahydrofuran; hexane; at 20 ℃; for 16h;

DOI:10.1002/chem.202101248

Reference yield: 46.0%

5-chloro-2-phenylindoline (593234-34-5) → (-)-(S)-5-chloro-2-phenylindoline (1448544-24-8)

Guidance literature:

With (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; N-(1-phenyl-ethylidene)-(3,4,5-trimethoxy-phenyl)-amine; In benzene; at 20 - 50 ℃; for 20h; enantioselective reaction; Molecular sieve; Inert atmosphere;

DOI:10.1021/ja406004q

upstream raw materials:

5-chloro-2-phenylindole

Downstream raw materials:

(-)-(S)-5-chloro-2-phenylindoline