23746-76-1

Basic information

• Product Name: 1H-INDOLE, 5-CHLORO-2-PHENYL-
• Synonyms: 5-CHLORO-2-PHENYL-1H-INDOLE;1H-INDOLE, 5-CHLORO-2-PHENYL-;2-phenyl-5-chloro-1H-indole
• CAS NO: 23746-76-1
• Molecular Formula: C₁₄H₁₀ClN
• Molecular Weight: 227.69
• Mol File: 23746-76-1.mol
• Article Data: 67

Chemical Properties

• Melting Point: 191 °C
• Boiling Point: 423.3±25.0 °C(Predicted)
• Appearance: /
• Density: 1.271±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 15.89±0.30(Predicted)
• CAS DataBase Reference: 1H-INDOLE, 5-CHLORO-2-PHENYL-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDOLE, 5-CHLORO-2-PHENYL-(23746-76-1)
• EPA Substance Registry System: 1H-INDOLE, 5-CHLORO-2-PHENYL-(23746-76-1)

Safety Data

• Hazardous Substances Data: 23746-76-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 46, p. 4511, 1981 DOI: 10.1021/jo00335a038

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Downstream Products

• 101735-70-0 5-chloro-1-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-phenyl-indole 
• 221695-56-3 (E)-5-chloro-3-(2-nitroethenyl)-2-phenyl-1H-indole 
• 872674-50-5 methyl (5-chloro-2-phenyl-1H-indol-3-yl)oxoacetate 
• 1749-62-8 2-(5-chloro-2-phenyl-indol-3-yl)-ethylamine 
• 7033-51-4 6-chloro-2-phenyl-benzo[d][1,3]oxazin-4-one 
• 1613132-78-7 C₁₇H₁₃ClN₄S 
• 1613132-84-5 C₁₇H₁₄ClN₅S 
• 1613132-90-3 6-(3-allyl-5-chloro-2-phenyl-1H-indol-1-yl)-5-amino-4,5-dihydro-1,2,4-triazine-3(2H)-thione 
• 1613132-96-9 1-(1-(5-amino-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-5-chloro-2-phenyl-1H-indol-3-yl)ethanone 
• 1613133-08-6 1-(5-amino-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-5-chloro-2-phenyl-1H-indole-3-carboxylic acid 
• 1613133-14-4 1-(5-amino-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-5-chloro-2-phenyl-1H-indole-3-carboxamide 
• 1610423-41-0 C₂₁H₂₃ClN₂O₂ 
• 85274-64-2 6-chloro-3-phenylquinolin-2(1H)-one 

Relevant articles and documents

DETERMINATION OF REACTIVITY CONSTANTS OF 5-SUBSTITUTED 2-INDOLYL GROUPS BY MEANS OF 13C NMR

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Synthesis of 2-Aryl- and 2-Vinyl-1H-indoles via Palladium-Catalyzed Cross-Coupling of Aryl and Vinyl Halides with 1-Carboxy-2-(tributylstannyl)indole

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Acid-catalyzed cleavage of C-C bonds enables atropaldehyde acetals as masked C2 electrophiles for organic synthesis

Acid-catalyzed tandem reactions of atropaldehyde acetals were established for the synthesis of three important molecules, 2,2-disubstituted indolin-3-ones, naphthofurans and stilbenes. The synthesis was realized using novel reaction cascades, which involved the same two initial steps: (i) SN2′ substitution, in which the atropaldehyde acted as an electrophile; and (ii) oxidative cleavage of the carbon-carbon bond of the generated phenylacetaldehyde-type products. Compared with literature methods, the present protocol not only avoided the use of expensive noble metal catalysts, but also enabled a simple operation.

Copper-Catalyzed Enantioselective C-H Arylation between 2-Arylindoles and Hypervalent Iodine Reagents

The copper-catalyzed enantioselective C-H arylation between 2-arylindoles and hypervalent iodine reagents has been successfully developed, which provides a convenient and economical route to the highly atroposelective synthesis of axially chiral indole de