9-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

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Chemical Name:9-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one
CAS No.:103920-97-4
Molecular Formula:C₂₀H₂₃ClN₂O₃S
Molecular Weight:406.933
Hs Code.:

Synonyms:9-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

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Chemical Property of 9-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

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Technology Process of 9-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

There total 7 articles about 9-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14371-77-8
6-chloro-2-nitrothiophenol

: 103920-97-4
9-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Guidance literature:: Multi-step reaction with 6 steps

1: 76.7 percent / Zn(OAc)2*2H₂O / toluene / 3 h / Ambient temperature

2: 90.2 percent / H₂, AcOH / 10percent Pd/C / ethanol / 11 h / Ambient temperature

3: 48.5 percent / NaH, DMSO / 0.08 h / Ambient temperature

4: 43.9 percent / pyridine / 18 h / Ambient temperature

5: 83.4 percent / aq. K₂CO₃ / methanol / 19 h / Ambient temperature

6: aq. K₂CO₃ / acetone / 17 h / Heating

With pyridine; zinc diacetate; hydrogen; sodium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; palladium on activated charcoal; In methanol; ethanol; acetone; toluene;
DOI:10.1021/jm00106a032

Reference yield:

: 96125-49-4
methyl trans-3-(4-methoxyphenyl)glycidate

: 103920-97-4
9-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Guidance literature:: Multi-step reaction with 6 steps

1: 76.7 percent / Zn(OAc)2*2H₂O / toluene / 3 h / Ambient temperature

2: 90.2 percent / H₂, AcOH / 10percent Pd/C / ethanol / 11 h / Ambient temperature

3: 48.5 percent / NaH, DMSO / 0.08 h / Ambient temperature

4: 43.9 percent / pyridine / 18 h / Ambient temperature

5: 83.4 percent / aq. K₂CO₃ / methanol / 19 h / Ambient temperature

6: aq. K₂CO₃ / acetone / 17 h / Heating

With pyridine; zinc diacetate; hydrogen; sodium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; palladium on activated charcoal; In methanol; ethanol; acetone; toluene;
DOI:10.1021/jm00106a032

Reference yield:

: 103921-05-7
3-(2-Chloro-6-nitro-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid methyl ester

: 103920-97-4
9-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: 90.2 percent / H₂, AcOH / 10percent Pd/C / ethanol / 11 h / Ambient temperature

2: 48.5 percent / NaH, DMSO / 0.08 h / Ambient temperature

3: 43.9 percent / pyridine / 18 h / Ambient temperature

4: 83.4 percent / aq. K₂CO₃ / methanol / 19 h / Ambient temperature

5: aq. K₂CO₃ / acetone / 17 h / Heating

With pyridine; hydrogen; sodium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; palladium on activated charcoal; In methanol; ethanol; acetone;
DOI:10.1021/jm00106a032