(+)-cis-(2S,3S)-9-chloro-2,3-dihydro-3-hydroxy-2-(4'-methoxyphenyl)-1,5-benzothiazepin-4-[5H]-one

Base Information

Chemical Name:(+)-cis-(2S,3S)-9-chloro-2,3-dihydro-3-hydroxy-2-(4'-methoxyphenyl)-1,5-benzothiazepin-4-[5H]-one
CAS No.:100902-62-3
Molecular Formula:C₁₆H₁₄ClNO₃S
Molecular Weight:335.811
Hs Code.:

Synonyms:(+)-cis-(2S,3S)-9-chloro-2,3-dihydro-3-hydroxy-2-(4'-methoxyphenyl)-1,5-benzothiazepin-4-[5H]-one

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Chemical Property of (+)-cis-(2S,3S)-9-chloro-2,3-dihydro-3-hydroxy-2-(4'-methoxyphenyl)-1,5-benzothiazepin-4-[5H]-one

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Technology Process of (+)-cis-(2S,3S)-9-chloro-2,3-dihydro-3-hydroxy-2-(4'-methoxyphenyl)-1,5-benzothiazepin-4-[5H]-one

There total 8 articles about (+)-cis-(2S,3S)-9-chloro-2,3-dihydro-3-hydroxy-2-(4'-methoxyphenyl)-1,5-benzothiazepin-4-[5H]-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.4%

: 100902-59-8
(S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid (2S,3S)-9-chloro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

: 100902-62-3
(+)-cis-(2S,3S)-9-chloro-2,3-dihydro-3-hydroxy-2-(4'-methoxyphenyl)-1,5-benzothiazepin-4-[5H]-one

Guidance literature:: With potassium carbonate; In methanol; for 19h; Ambient temperature;
DOI:10.1021/jm00106a032

Reference yield:

: 14371-77-8
6-chloro-2-nitrothiophenol

: 100902-62-3
(+)-cis-(2S,3S)-9-chloro-2,3-dihydro-3-hydroxy-2-(4'-methoxyphenyl)-1,5-benzothiazepin-4-[5H]-one

Guidance literature:: Multi-step reaction with 5 steps

1: 76.7 percent / Zn(OAc)2*2H₂O / toluene / 3 h / Ambient temperature

2: 90.2 percent / H₂, AcOH / 10percent Pd/C / ethanol / 11 h / Ambient temperature

3: 48.5 percent / NaH, DMSO / 0.08 h / Ambient temperature

4: 43.9 percent / pyridine / 18 h / Ambient temperature

5: 83.4 percent / aq. K₂CO₃ / methanol / 19 h / Ambient temperature

With pyridine; zinc diacetate; hydrogen; sodium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; palladium on activated charcoal; In methanol; ethanol; toluene;
DOI:10.1021/jm00106a032

Reference yield:

: 96125-49-4
methyl trans-3-(4-methoxyphenyl)glycidate

: 100902-62-3
(+)-cis-(2S,3S)-9-chloro-2,3-dihydro-3-hydroxy-2-(4'-methoxyphenyl)-1,5-benzothiazepin-4-[5H]-one

Guidance literature:: Multi-step reaction with 5 steps

1: 76.7 percent / Zn(OAc)2*2H₂O / toluene / 3 h / Ambient temperature

2: 90.2 percent / H₂, AcOH / 10percent Pd/C / ethanol / 11 h / Ambient temperature

3: 48.5 percent / NaH, DMSO / 0.08 h / Ambient temperature

4: 43.9 percent / pyridine / 18 h / Ambient temperature

5: 83.4 percent / aq. K₂CO₃ / methanol / 19 h / Ambient temperature

With pyridine; zinc diacetate; hydrogen; sodium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; palladium on activated charcoal; In methanol; ethanol; toluene;
DOI:10.1021/jm00106a032