(2R,4R)-1-Benzyl-4-(tert-butyl-dimethyl-silanyloxy)-2-vinyl-pyrrolidine

Base Information

Chemical Name:(2R,4R)-1-Benzyl-4-(tert-butyl-dimethyl-silanyloxy)-2-vinyl-pyrrolidine
CAS No.:154343-07-4
Molecular Formula:C₁₉H₃₁NOSi
Molecular Weight:317.547
Hs Code.:

Synonyms:(2R,4R)-1-Benzyl-4-(tert-butyl-dimethyl-silanyloxy)-2-vinyl-pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4R)-1-Benzyl-4-(tert-butyl-dimethyl-silanyloxy)-2-vinyl-pyrrolidine

Chemical Property:

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Technology Process of (2R,4R)-1-Benzyl-4-(tert-butyl-dimethyl-silanyloxy)-2-vinyl-pyrrolidine

There total 1 articles about (2R,4R)-1-Benzyl-4-(tert-butyl-dimethyl-silanyloxy)-2-vinyl-pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2065-66-9
methyl-triphenylphosphonium iodide

: 1-benzyl-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-2-carbaldehyde

: 156441-18-8
(2S,4R)-1-benzyl-4-tert-butyldimethylsilyloxy-2-vinylpyrrolidine

: 154343-07-4
(2R,4R)-1-Benzyl-4-(tert-butyl-dimethyl-silanyloxy)-2-vinyl-pyrrolidine

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃; for 16h; Yield given; Yields of byproduct given;
DOI:10.1002/(SICI)1521-3773(19980504)37:8<1140::AID-ANIE1140>3.0.CO;2-W

Reference yield:

: 79-04-9
chloroacetyl chloride

: 154343-07-4
(2R,4R)-1-Benzyl-4-(tert-butyl-dimethyl-silanyloxy)-2-vinyl-pyrrolidine

: 209164-30-7
(E)-(3R,8R)-1-Benzyl-8-(tert-butyl-dimethyl-silanyloxy)-3-chloro-1,3,4,7,8,9-hexahydro-azonin-2-one

Guidance literature:: With trimethylaluminum; potassium carbonate; In chloroform; at 0 ℃; for 24h;
DOI:10.1002/(SICI)1521-3773(19980504)37:8<1140::AID-ANIE1140>3.0.CO;2-W

Reference yield:

: 154343-07-4
(2R,4R)-1-Benzyl-4-(tert-butyl-dimethyl-silanyloxy)-2-vinyl-pyrrolidine

: 2R,6R,8S,8aR-2-(tert-butyldimethylsilyloxy)-6-chloro-8-phenylselanyl-5(8H)-indolizidinone

Guidance literature:: Multi-step reaction with 2 steps

1: Me₃Al, K₂CO₃ / CHCl₃ / 24 h / 0 °C

2: acetonitrile / 3 h / 20 °C

With trimethylaluminum; potassium carbonate; In chloroform; acetonitrile;
DOI:10.1002/(SICI)1521-3773(19980504)37:8<1140::AID-ANIE1140>3.0.CO;2-W