6-(1H-indazol-6-yl)-N-(4-(piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine

Base Information

Chemical Name:6-(1H-indazol-6-yl)-N-(4-(piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine
CAS No.:1229210-01-8
Molecular Formula:C₂₃H₂₂N₈
Molecular Weight:410.481
Hs Code.:

Synonyms:6-(1H-indazol-6-yl)-N-(4-(piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine

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Chemical Property of 6-(1H-indazol-6-yl)-N-(4-(piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine

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Technology Process of 6-(1H-indazol-6-yl)-N-(4-(piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine

There total 6 articles about 6-(1H-indazol-6-yl)-N-(4-(piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: tert-butyl 4-(4-((6-(1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)piperazine-1-carboxylate

: 1229210-01-8
6-(1H-indazol-6-yl)-N-(4-(piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 0 ℃; for 3h;
DOI:10.1016/j.bioorg.2019.103547

Reference yield:

: 1021154-34-6
tert-butyl 4-(4-((6-bromoimidazo[1,2-a]pyrazin-8-yl)amino)phenyl)piperazine-1-carboxylate

: 1229210-01-8
6-(1H-indazol-6-yl)-N-(4-(piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,4-dioxane / 100 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 3 h / 0 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; water; 1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bioorg.2019.103547

Reference yield:

: 182618-86-6
tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate

: 1229210-01-8
6-(1H-indazol-6-yl)-N-(4-(piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrazine hydrate / ethanol / 8 h / 75 °C

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 8 h / 85 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,4-dioxane / 100 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane / 3 h / 0 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; sodium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; water; isopropyl alcohol; 3: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bioorg.2019.103547