tert-butyl 4-(4-((6-bromoimidazo[1,2-a]pyrazin-8-yl)amino)phenyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-((6-bromoimidazo[1,2-a]pyrazin-8-yl)amino)phenyl)piperazine-1-carboxylate
CAS No.:1021154-34-6
Molecular Formula:C₂₁H₂₅BrN₆O₂
Molecular Weight:473.373
Hs Code.:

Synonyms:tert-butyl 4-(4-((6-bromoimidazo[1,2-a]pyrazin-8-yl)amino)phenyl)piperazine-1-carboxylate

Suppliers and Price of tert-butyl 4-(4-((6-bromoimidazo[1,2-a]pyrazin-8-yl)amino)phenyl)piperazine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 4-(4-((6-bromoimidazo[1,2-a]pyrazin-8-yl)amino)phenyl)piperazine-1-carboxylate

Chemical Property:

Density:1.47±0.1 g/cm3(Predicted)

Purity/Quality:

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Technology Process of tert-butyl 4-(4-((6-bromoimidazo[1,2-a]pyrazin-8-yl)amino)phenyl)piperazine-1-carboxylate

There total 4 articles about tert-butyl 4-(4-((6-bromoimidazo[1,2-a]pyrazin-8-yl)amino)phenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 63744-22-9
6,8-dibromoimidazo[1,2-a]pyrazine

: 170911-92-9
4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine

: 1021154-34-6
tert-butyl 4-(4-((6-bromoimidazo[1,2-a]pyrazin-8-yl)amino)phenyl)piperazine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 85 ℃; for 8h;
DOI:10.1016/j.bioorg.2019.103547

Reference yield:

: 182618-86-6
tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate

: 1021154-34-6
tert-butyl 4-(4-((6-bromoimidazo[1,2-a]pyrazin-8-yl)amino)phenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrazine hydrate / ethanol / 8 h / 75 °C

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 8 h / 85 °C

With palladium 10% on activated carbon; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In ethanol; isopropyl alcohol;
DOI:10.1016/j.bioorg.2019.103547

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1021154-34-6
tert-butyl 4-(4-((6-bromoimidazo[1,2-a]pyrazin-8-yl)amino)phenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 80 °C

2: palladium 10% on activated carbon; hydrazine hydrate / ethanol / 8 h / 75 °C

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 8 h / 85 °C

With palladium 10% on activated carbon; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In ethanol; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.bioorg.2019.103547