[5-(3-Fluorophenyl)furan-2-yl]methanamine

Base Information

• Chemical Name: [5-(3-Fluorophenyl)furan-2-yl]methanamine
• CAS No.: 39170-15-5
• Molecular Formula: C₁₁H₁₀FNO
• Molecular Weight: 191.205
• DSSTox Substance ID: DTXSID901288278
• Mol file: 39170-15-5.mol

Synonyms:39170-15-5;[5-(3-fluorophenyl)furan-2-yl]methanamine;2-Furanmethanamine, 5-(3-fluorophenyl)-;(5-(3-Fluorophenyl)furan-2-yl)methanamine;DTXSID901288278;5-(3-Fluorophenyl)-2-furanmethanamine;CS-0269143;EN300-2712252

Chemical Property of [5-(3-Fluorophenyl)furan-2-yl]methanamine

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 191.074642105
• Heavy Atom Count: 14
• Complexity: 188

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)F)C2=CC=C(O2)CN

Technology Process of [5-(3-Fluorophenyl)furan-2-yl]methanamine

There total 2 articles about [5-(3-Fluorophenyl)furan-2-yl]methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

meta-fluoroaniline (372-19-0) + furan-2-ylmethanamine (617-89-0) → 5-(m-Fluorphenyl)-2-aminomethyl-furan (39170-15-5)

Guidance literature:

meta-fluoroaniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃;

furan-2-ylmethanamine; With hydrogenchloride; titanium(III) chloride; In water; at 0 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201600377

Reference yield:

→ 5-(m-Fluorphenyl)-2-aminomethyl-furan (39170-15-5)

Guidance literature:

Furfuraloxim Ic, Zn/Eg.;

DOI:10.1007/BF00471858

Reference yield: 70.0%

5-(m-Fluorphenyl)-2-aminomethyl-furan (39170-15-5) → 6-(3-fluorophenyl)pyridin-3-ol

Guidance literature:

With bromine; In methanol; water; at 0 - 20 ℃; for 18h;

DOI:10.1002/ejoc.201600377

upstream raw materials:

meta-fluoroaniline

furan-2-ylmethanamine