4-<(Benzyloxy)methyl>-2,6-dimethoxy-3-pyridinecarbamic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: 4-<(Benzyloxy)methyl>-2,6-dimethoxy-3-pyridinecarbamic acid 1,1-dimethylethyl ester
• CAS No.: 162709-27-5
• Molecular Formula: C₂₀H₂₆N₂O₅
• Molecular Weight: 374.437
• Mol file: 162709-27-5.mol

Synonyms:4-<(Benzyloxy)methyl>-2,6-dimethoxy-3-pyridinecarbamic acid 1,1-dimethylethyl ester

Chemical Property of 4-<(Benzyloxy)methyl>-2,6-dimethoxy-3-pyridinecarbamic acid 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<(Benzyloxy)methyl>-2,6-dimethoxy-3-pyridinecarbamic acid 1,1-dimethylethyl ester

There total 1 articles about 4-<(Benzyloxy)methyl>-2,6-dimethoxy-3-pyridinecarbamic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Benzyloxymethyl chloride (3587-60-8) + 3-(tert-butoxycarbonylamino)-2,6-dimethoxypyridine (161117-86-8) → 4-<(Benzyloxy)methyl>-2,6-dimethoxy-3-pyridinecarbamic acid 1,1-dimethylethyl ester (162709-27-5)

Guidance literature:

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; hexane; 1.) -78 to -10 deg C, 2 h, 2.) -78 deg C to r.t., 3 h;

DOI:10.1021/jo00111a056

Reference yield:

4-<(Benzyloxy)methyl>-2,6-dimethoxy-3-pyridinecarbamic acid 1,1-dimethylethyl ester (162709-27-5) → 3-amino-4-<(benzyloxy)methyl>-2,6-dimethoxypyridine (172326-47-5)

Guidance literature:

With hydrogenchloride; In ethyl acetate;

DOI:10.1021/jm00024a011

Reference yield:

4-<(Benzyloxy)methyl>-2,6-dimethoxy-3-pyridinecarbamic acid 1,1-dimethylethyl ester (162709-27-5) → 9-Benzyloxymethyl-5-ethyl-7-hydroxy-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one (172326-33-9)

Guidance literature:

Multi-step reaction with 5 steps

1: HCl / ethyl acetate

2: 47 percent / i-PrNEt₂ / ethyl acetate / 0 °C

3: 94 percent / 110 °C

4: 77 percent / NaHMDS, pyridine / 90 °C

5: 37 percent / LiI, 2,6-collidine / 2 h / 160 °C

With pyridine; 2,4,6-trimethyl-pyridine; hydrogenchloride; N,N-diethyl-N-isopropylamine; sodium hexamethyldisilazane; lithium iodide; In ethyl acetate;

DOI:10.1021/jm00024a011

upstream raw materials:

Benzyloxymethyl chloride

3-(tert-butoxycarbonylamino)-2,6-dimethoxypyridine

Downstream raw materials:

3-amino-4-<(benzyloxy)methyl>-2,6-dimethoxypyridine

9-Benzyloxymethyl-5-ethyl-7-hydroxy-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

9-Benzyloxymethyl-5-ethyl-7-methoxy-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

2-chloro-N-<4-<(benzyloxy)methyl>-2,6-dimethoxy-3-pyridinyl>-3-pyridinecarboxamide