4-benzylamino-2,5-dihydro-pyrrole-1,3-dicarboxylic acid di-tert-butyl ester

Base Information

• Chemical Name: 4-benzylamino-2,5-dihydro-pyrrole-1,3-dicarboxylic acid di-tert-butyl ester
• CAS No.: 341969-57-1
• Molecular Formula: C₂₁H₃₀N₂O₄
• Molecular Weight: 374.48

Synonyms:4-benzylamino-2,5-dihydro-pyrrole-1,3-dicarboxylic acid di-tert-butyl ester

Chemical Property of 4-benzylamino-2,5-dihydro-pyrrole-1,3-dicarboxylic acid di-tert-butyl ester

Chemical Property:

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Technology Process of 4-benzylamino-2,5-dihydro-pyrrole-1,3-dicarboxylic acid di-tert-butyl ester

There total 1 articles about 4-benzylamino-2,5-dihydro-pyrrole-1,3-dicarboxylic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-Butyl acrylate (1663-39-4,25232-27-3) + N-(tert-butoxycarbonyl)glycine methyl ester (31954-27-5) + benzylamine acetic acid (2182-52-7) → 4-benzylamino-2,5-dihydro-pyrrole-1,3-dicarboxylic acid di-tert-butyl ester (341969-57-1)

Guidance literature:

tert-Butyl acrylate; N-(tert-butoxycarbonyl)glycine methyl ester; With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 24h;

benzylamine acetic acid; With acetic acid; In methanol; for 1.5h; Further stages.; Heating;

DOI:10.1021/jm000468c

Reference yield: 92.0%

4-benzylamino-2,5-dihydro-pyrrole-1,3-dicarboxylic acid di-tert-butyl ester (341969-57-1) → (3R,4S)-4-Benzylamino-pyrrolidine-1,3-dicarboxylic acid di-tert-butyl ester + (3R,4R)-4-Benzylamino-pyrrolidine-1,3-dicarboxylic acid di-tert-butyl ester

Guidance literature:

With sodium tetrahydroborate; acetic acid; at 10 - 15 ℃; for 6h;

DOI:10.1021/jm000468c

upstream raw materials:

tert-Butyl acrylate

N-(tert-butoxycarbonyl)glycine methyl ester

benzylamine acetic acid

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