1-[2-(2-Methoxy-ethoxy)-4-phenylsulfanylmethyl-cyclohex-3-enyl]-ethanone

Base Information

• Chemical Name: 1-[2-(2-Methoxy-ethoxy)-4-phenylsulfanylmethyl-cyclohex-3-enyl]-ethanone
• CAS No.: 345931-00-2
• Molecular Formula: C₁₈H₂₄O₃S
• Molecular Weight: 320.453
• Mol file: 345931-00-2.mol

Synonyms:1-[2-(2-Methoxy-ethoxy)-4-phenylsulfanylmethyl-cyclohex-3-enyl]-ethanone

Chemical Property of 1-[2-(2-Methoxy-ethoxy)-4-phenylsulfanylmethyl-cyclohex-3-enyl]-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-(2-Methoxy-ethoxy)-4-phenylsulfanylmethyl-cyclohex-3-enyl]-ethanone

There total 6 articles about 1-[2-(2-Methoxy-ethoxy)-4-phenylsulfanylmethyl-cyclohex-3-enyl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

1-(β-methoxyethoxy)-3-<(phenylthio)methyl>-1,3-butadiene (86531-07-9,86531-35-3) + methyl vinyl ketone (78-94-4,25038-87-3) → 1-[2-(2-Methoxy-ethoxy)-4-phenylsulfanylmethyl-cyclohex-3-enyl]-ethanone (345931-00-2)

Guidance literature:

With hydroquinone; In benzene; for 24h; Ambient temperature;

DOI:10.1021/jo00193a028

Reference yield:

3-(phenylthio)propionaldehyde diethyl acetal (57432-86-7) → 1-[2-(2-Methoxy-ethoxy)-4-phenylsulfanylmethyl-cyclohex-3-enyl]-ethanone (345931-00-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 50 percent / Me₂NH*HCl, hydroquinone / H₂O / 2 h / 100 °C

2: 36 percent / tetrahydrofuran / 1 h / Ambient temperature

3: 57 percent / hydroquinone / benzene / 24 h / Ambient temperature

With N,N-dimethylammonium chloride; hydroquinone; In tetrahydrofuran; water; benzene;

DOI:10.1021/jo00193a028

Reference yield:

3-(phenylthio)-2-methylenepropan-1-al (86531-03-5) → 1-[2-(2-Methoxy-ethoxy)-4-phenylsulfanylmethyl-cyclohex-3-enyl]-ethanone (345931-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 36 percent / tetrahydrofuran / 1 h / Ambient temperature

2: 57 percent / hydroquinone / benzene / 24 h / Ambient temperature

With hydroquinone; In tetrahydrofuran; benzene;

DOI:10.1021/jo00193a028

upstream raw materials:

1-(β-methoxyethoxy)-3-<(phenylthio)methyl>-1,3-butadiene

methyl vinyl ketone

(E)-1-(β-methoxyethoxy)-3-<(phenylthio)methyl>-1,3-butadiene

3-(phenylthio)propionaldehyde diethyl acetal

Downstream raw materials:

1-(4-Phenylsulfanylmethyl-cyclohexa-1,3-dienyl)-ethanone