3-(2-(1-(S)-amino-2-(pyridin-2-yl)ethyl)phenyl)benzo[d]isoxazole-6-carboxamide

Base Information

Chemical Name:3-(2-(1-(S)-amino-2-(pyridin-2-yl)ethyl)phenyl)benzo[d]isoxazole-6-carboxamide
CAS No.:1261603-61-5
Molecular Formula:C₂₁H₁₈N₄O₂
Molecular Weight:358.4
Hs Code.:

Synonyms:3-(2-(1-(S)-amino-2-(pyridin-2-yl)ethyl)phenyl)benzo[d]isoxazole-6-carboxamide

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Chemical Property of 3-(2-(1-(S)-amino-2-(pyridin-2-yl)ethyl)phenyl)benzo[d]isoxazole-6-carboxamide

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Technology Process of 3-(2-(1-(S)-amino-2-(pyridin-2-yl)ethyl)phenyl)benzo[d]isoxazole-6-carboxamide

There total 11 articles about 3-(2-(1-(S)-amino-2-(pyridin-2-yl)ethyl)phenyl)benzo[d]isoxazole-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1261604-15-2
3-(2-((S)-1-((S)-1,1-dimethylethylsulfinamido)-2-(pyridin-2-yl)ethyl)phenyl)benzo[d]isoxazole-6-carboxamide

: 1261603-61-5
3-(2-(1-(S)-amino-2-(pyridin-2-yl)ethyl)phenyl)benzo[d]isoxazole-6-carboxamide

Guidance literature:: With hydrogenchloride; In methanol; diethyl ether; at 20 ℃; for 2.5h;

Reference yield:

: 57848-46-1
4-bromo-2-fluorobenzaldehyde

: 1261603-61-5
3-(2-(1-(S)-amino-2-(pyridin-2-yl)ethyl)phenyl)benzo[d]isoxazole-6-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: hexane; diethyl ether / 1.25 h / -70 - -60 °C / Inert atmosphere

1.2: 4 h / -60 - 10 °C

2.1: sodium hydrogencarbonate; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water; tert-butyl alcohol / 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

3.2: 6.33 h / 20 °C / Inert atmosphere; Reflux

4.1: hydrogenchloride / ethanol / 0.33 h / 70 °C

5.1: toluene-4-sulfonic acid / ethanol / 0.75 h / 45 °C

6.1: n-butyllithium / diethyl ether / 0.75 h / -78 °C / Inert atmosphere

6.2: -78 - 20 °C

7.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 2 h / 20 °C / Inert atmosphere

7.2: 2 h / 20 °C

8.1: titanium(IV) tetraethanolate / tetrahydrofuran / 72 h

9.1: n-butyllithium / hexane; tetrahydrofuran / 1.42 h / -72 - -70 °C / Inert atmosphere

9.2: 1.25 h / -70 °C

10.1: hydrogenchloride / diethyl ether; methanol / 2.5 h / 20 °C

With hydrogenchloride; titanium(IV) tetraethanolate; n-butyllithium; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; potassium tert-butylate; sodium hydrogencarbonate; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; ethanol; hexane; water; tert-butyl alcohol;

Reference yield:

: 35822-58-3
2-bromobenzaldehyde diethyl acetal

: 1261603-61-5
3-(2-(1-(S)-amino-2-(pyridin-2-yl)ethyl)phenyl)benzo[d]isoxazole-6-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: hexane; diethyl ether / 1.25 h / -70 - -60 °C / Inert atmosphere

1.2: 4 h / -60 - 10 °C

2.1: sodium hydrogencarbonate; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water; tert-butyl alcohol / 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

3.2: 6.33 h / 20 °C / Inert atmosphere; Reflux

4.1: hydrogenchloride / ethanol / 0.33 h / 70 °C

5.1: toluene-4-sulfonic acid / ethanol / 0.75 h / 45 °C

6.1: n-butyllithium / diethyl ether / 0.75 h / -78 °C / Inert atmosphere

6.2: -78 - 20 °C

7.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 2 h / 20 °C / Inert atmosphere

7.2: 2 h / 20 °C

8.1: titanium(IV) tetraethanolate / tetrahydrofuran / 72 h

9.1: n-butyllithium / hexane; tetrahydrofuran / 1.42 h / -72 - -70 °C / Inert atmosphere

9.2: 1.25 h / -70 °C

10.1: hydrogenchloride / diethyl ether; methanol / 2.5 h / 20 °C

With hydrogenchloride; titanium(IV) tetraethanolate; n-butyllithium; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; potassium tert-butylate; sodium hydrogencarbonate; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; ethanol; hexane; water; tert-butyl alcohol;