2-(3-((3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylamino)-2-hydroxypropylamino)quinolin-4(1H)-one

Base Information

Chemical Name:2-(3-((3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylamino)-2-hydroxypropylamino)quinolin-4(1H)-one
CAS No.:1427697-24-2
Molecular Formula:C₂₈H₂₆FN₅O₂
Molecular Weight:483.545
Hs Code.:

Synonyms:2-(3-((3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylamino)-2-hydroxypropylamino)quinolin-4(1H)-one

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Chemical Property of 2-(3-((3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylamino)-2-hydroxypropylamino)quinolin-4(1H)-one

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Technology Process of 2-(3-((3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylamino)-2-hydroxypropylamino)quinolin-4(1H)-one

There total 2 articles about 2-(3-((3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylamino)-2-hydroxypropylamino)quinolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1-amino-3-[4-(4-methoxybenzyloxy) quinolin-2-yl-amino]propan-2-ol

: 36640-40-1
3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde

: 1427697-24-2
2-(3-((3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylamino)-2-hydroxypropylamino)quinolin-4(1H)-one

Guidance literature:: 1-amino-3-[4-(4-methoxybenzyloxy) quinolin-2-yl-amino]propan-2-ol; With sodium methylate; acetic acid; In methanol; at 20 ℃; for 0.25h;

3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde; In methanol; at 50 ℃; for 1h;

With sodium cyanoborohydride; In methanol; at 50 ℃; for 6h;
DOI:10.1002/jhet.1040

Reference yield:

: 733053-60-6
2-chloro-4-(4-methoxybenzyloxy)quinoline

: 1427697-24-2
2-(3-((3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylamino)-2-hydroxypropylamino)quinolin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / dimethyl sulfoxide / 48 h / 80 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.1: acetic acid; sodium methylate / methanol / 0.25 h / 20 °C

3.2: 1 h / 50 °C

3.3: 6 h / 50 °C

With sodium methylate; potassium carbonate; acetic acid; trifluoroacetic acid; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1002/jhet.1040